Mechanisms, applications, and challenges of insect RNA interference

KY Zhu, SR Palli - Annual review of entomology, 2020 - annualreviews.org
The RNA interference (RNAi) triggered by short/small interfering RNA (siRNA) was
discovered in nematodes and found to function in most living organisms. RNAi has been …

Double-stranded RNA technology to control insect pests: current status and challenges

O Christiaens, S Whyard, AM Vélez… - Frontiers in Plant …, 2020 - frontiersin.org
Exploiting the RNA interference (RNAi) gene mechanism to silence essential genes in pest
insects, leading to toxic effects, has surfaced as a promising new control strategy in the past …

Development and characterization of the first dsRNA-resistant insect population from western corn rootworm, Diabrotica virgifera virgifera LeConte

C Khajuria, S Ivashuta, E Wiggins, L Flagel, W Moar… - PloS one, 2018 - journals.plos.org
The use of dsRNA to control insect pests via the RNA interference (RNAi) pathway is being
explored by researchers globally. However, with every new class of insect control …

DsRNA-based pesticides: Considerations for efficiency and risk assessment

A Dalakouras, V Koidou, K Papadopoulou - Chemosphere, 2024 - Elsevier
In view of the ongoing climate change and the ever-growing world population, novel
agricultural solutions are required to ensure sustainable food supply. Microbials, natural …

Biotechnological approaches for host plant resistance to insect pests

P Kumari, P Jasrotia, D Kumar, PL Kashyap… - Frontiers in …, 2022 - frontiersin.org
Annually, the cost of insect pest control in agriculture crosses billions of dollars around the
world. Until recently, broad-spectrum synthetic pesticides were considered as the most …

Implementation of RNAi-based arthropod pest control: environmental risks, potential for resistance and regulatory considerations

O Christiaens, J Sweet, T Dzhambazova, I Urru… - Journal of Pest …, 2022 - Springer
Just over 20 years since the RNA interference (RNAi) mechanism was unraveled in the
nematode Caenorhabditis elegans, the first RNAi-based pest control applications are close …

Establishing RNAi for basic research and pest control and identification of the most efficient target genes for pest control: a brief guide

S Mehlhorn, VS Hunnekuhl, S Geibel, R Nauen… - Frontiers in …, 2021 - Springer
RNA interference (RNAi) has emerged as a powerful tool for knocking-down gene function
in diverse taxa including arthropods for both basic biological research and application in …

The mysteries of insect RNAi: A focus on dsRNA uptake and transport

AM Vélez, E Fishilevich - Pesticide biochemistry and physiology, 2018 - Elsevier
RNA interference (RNAi) is becoming a practical tool to control insect pests. Many mysteries
of how double-stranded RNA (dsRNA) is transported into, within, and between cells to …

RNAi for western corn rootworm management: Lessons learned, challenges, and future directions

M Darlington, JD Reinders, A Sethi, AL Lu… - Insects, 2022 - mdpi.com
Simple Summary The western corn rootworm (WCR), Diabrotica virgifera virgifera LeConte,
is an annual pest of maize in the United States Corn Belt. Larval feeding on the root system …

Extracellular RNA is transported from one generation to the next in Caenorhabditis elegans

J Marré, EC Traver, AM Jose - Proceedings of the National …, 2016 - National Acad Sciences
Experiences during the lifetime of an animal have been proposed to have consequences for
subsequent generations. Although it is unclear how such intergenerational transfer of …