Natural killer (NK) cells are a critical component of the innate immune system. Chimeric
antigen receptors (CARs) re-direct NK cells toward tumor cells carrying corresponding …

The leishmaniases are diseases caused by pathogenic protozoan parasites of the genus
Leishmania. Infections are initiated when a sand fly vector inoculates Leishmania parasites …

Natural Killer (NK) cells are lymphocytes of the innate immunity that play a crucial role in the
control of viral infections in the absence of a prior antigen sensitization. Indeed, they display …

The immunotherapy of cancer has made significant strides in the past few years due to
improved understanding of the underlying principles of tumor biology and immunology …

Naive T cells are stimulated by antigen-presenting dendritic cells (DCs) in secondary
lymphoid organs, but whether other types of cell participate in T cell priming is unclear. Here …

Autocrine and paracrine cell communication can be conveyed by multiple mediators,
including membrane-associate proteins, secreted proteins and exosomes. Exosomes are 30 …

Purpose: Tumor antigen–specific monoclonal antibodies (mAb) block oncogenic signaling
and induce Fcγ receptor (FcγR)–mediated cytotoxicity. However, the role of CD8+ CTL and …

In children, cancer probably arises from a combination of inherited genetic mutations and
genetic alterations that are acquired during the rapid cellular expansion that occurs during …

Several recent publications have focused on the newly described interactions between
natural-killer (NK) cells and dendritic cells (DCs). Activated NK cells induce DC maturation …

Dendritic cells (DCs) are known to induce the growth and function of natural killer (NK) cells.
Here, we address the capacity of DCs to interact with NK cells in human lymphoid organs …