Mutations in methyl CpG binding protein 2 (MeCP2) are the major cause of Rett syndrome
(RTT), a rare neurodevelopmental disorder with a notable period of developmental …

Repetitive elements (REs), such as transposable elements (TEs) and satellites, comprise
much of the genome. Here, we review how TEs and (peri) centromeric satellite DNA may …

Parkinson's disease is a complex neurodegenerative disorder with a strong genetic
component, for which most known disease-associated variants are single nucleotide …

Mental illness remains the greatest chronic health burden globally with few in-roads having
been made despite significant advances in genomic knowledge in recent decades. The field …

Extrachromosomal circular DNAs (eccDNAs) are widely observed in eukaryotes. Previous
studies have demonstrated that eccDNAs are essential to cancer progression, and found …

Transposable elements (TEs) are repetitive elements that belong to a variety of functional
classes and have an important role in shaping genome evolution. Around 50% of the human …

The long interspersed nuclear element-1 (L1) is a retrotransposon that constitutes 17% of
the human genome and is associated with various diseases and aging. Estimates suggest …

Age is a major risk factor for neurodegenerative diseases like Parkinson's disease, but few
studies have explored the contribution of key hallmarks of aging, namely DNA methylation …

Pericentromeric heterochromatin is mainly composed of satellite DNA sequences. Although
being historically associated with transcriptional repression, some pericentromeric satellite …

Progress in genomic analytical technologies has improved our possibilities to obtain
information regarding DNA, RNA, and their dynamic changes that occur over time or in …