Nonheme iron-dependent enzymatic reactions play crucial roles in building and modifying
bioactive organic molecules in all major classes of natural product pathways. While the …

Azaserine is a bacterial metabolite containing a biologically unusual and synthetically
enabling α‐diazoester functional group. Herein, we report the discovery of the azaserine …

Multinuclear non-heme iron dependent oxidative enzymes (MNIOs), formerly known as
domain of unknown function 692 (DUF692), are involved in the post-translational …

Nitriles are uncommon in nature and are typically constructed from oximes through the
oxidative decarboxylation of amino acid substrates or from the derivatization of carboxylic …

Upon oxygen activation, the non-heme diiron enzymes can generate various active species
for oxidative transformations. In this work, the catalytic mechanism of the diiron active site …

Chlamydia protein associating with death domains (CADD) is involved in the biosynthesis of
para-aminobenzoate (pABA), an essential component of the folate cofactor that is required …

The biosynthesis of neurotoxin aetokthonotoxin (AETX) that features a unique structure of
pentabrominated biindole nitrile involves a first-of-its-kind nitrile synthase termed AetD, an …

Valanimycin is an azoxy‐containing natural product isolated from the fermentation broth of
Streptomyces viridifaciens MG456‐hF10. While the biosynthesis of valanimycin has been …

Terminal olefins synthesized by the decarboxylation of fatty acids are important platform
chemicals. PfUndA is a nonheme di-iron oxidase capable of converting medium-chain (C …

The MbnBC enzyme complex converts cysteine residues in a peptide substrate, MbnA, to
oxazolone/thioamide groups during the biosynthesis of copper chelator methanobactin …