[HTML][HTML] Hyaluronic acid and its biomedical applications: A review

M Dovedytis, ZJ Liu, S Bartlett - Engineered Regeneration, 2020 - Elsevier
Hyaluronic acid is a naturally occurring biopolymer possessing numerous functions within
the body including wound repair, cell migration, and cell signaling. Due to its versatility …

Hyaluronic acid: A review on its biology, aspects of drug delivery, route of administrations and a special emphasis on its approved marketed products and recent …

S Vasvani, P Kulkarni, D Rawtani - International journal of biological …, 2020 - Elsevier
Hyaluronic acid (HA) is a large non-sulphated glycosaminoglycan that is an important
component of extracellular matrix (ECM) and a biodegradable polymer. Due to a variation in …

Hyaluronan: molecular size‐dependent signaling and biological functions in inflammation and cancer

AG Tavianatou, I Caon, M Franchi… - The FEBS …, 2019 - Wiley Online Library
Hyaluronan (HA) is a linear nonsulfated glycosaminoglycan of the extracellular matrix that
plays a pivotal role in a variety of biological processes. High‐molecular weight HA exhibits …

High and low molecular weight hyaluronic acid differentially influence macrophage activation

JE Rayahin, JS Buhrman, Y Zhang… - ACS biomaterials …, 2015 - ACS Publications
Macrophages exhibit phenotypic diversity permitting wide-ranging roles in maintaining
physiologic homeostasis. Hyaluronic acid, a major glycosaminoglycan of the extracellular …

Hyaluronan as an immune regulator in human diseases

D Jiang, J Liang, PW Noble - Physiological reviews, 2011 - journals.physiology.org
Accumulation and turnover of extracellular matrix components are the hallmarks of tissue
injury. Fragmented hyaluronan stimulates the expression of inflammatory genes by a variety …

Synthesis and characterization of hybrid hyaluronic acid-gelatin hydrogels

G Camci-Unal, D Cuttica, N Annabi… - …, 2013 - ACS Publications
Biomimetic hybrid hydrogels have generated broad interest in tissue engineering and
regenerative medicine. Hyaluronic acid (HA) and gelatin (hydrolyzed collagen) are naturally …

Hyaluronic acid as a modern approach in anticancer therapy-review

M Michalczyk, E Humeniuk, G Adamczuk… - International Journal of …, 2022 - mdpi.com
Hyaluronic acid (HA) is a linear polysaccharide and crucial component of the extracellular
matrix (ECM), maintaining tissue hydration and tension. Moreover, HA contributes to …

Hyaluronan: A modulator of the tumor microenvironment

T Chanmee, P Ontong, N Itano - Cancer Letters, 2016 - Elsevier
Tumors are cellular masses formed through dynamic interactions between tumor cells and a
mixed population of stromal cells. Crosstalk between oncogenic and adjacent stromal cells …

The high and low molecular weight forms of hyaluronan have distinct effects on CD44 clustering

C Yang, M Cao, H Liu, Y He, J Xu, Y Du, Y Liu… - Journal of Biological …, 2012 - ASBMB
CD44 is a major cell surface receptor for the glycosaminoglycan hyaluronan (HA). Native
high molecular weight hyaluronan (nHA) and oligosaccharides of hyaluronan (oHA) provoke …

The role of CD44 in pathological angiogenesis

L Chen, C Fu, Q Zhang, C He, F Zhang… - The FASEB …, 2020 - Wiley Online Library
Angiogenesis is required for normal development and occurs as a pathological step in a
variety of disease settings, such as cancer, ocular diseases, and ischemia. Recent studies …