Cell and circuit complexity of the external globus pallidus
The external globus pallidus (GPe) of the basal ganglia has been underappreciated owing
to poor understanding of its cells and circuits. It was assumed that the GPe consisted of a …
to poor understanding of its cells and circuits. It was assumed that the GPe consisted of a …
Ventral pallidal regulation of motivated behaviors and reinforcement
C Soares-Cunha, JA Heinsbroek - Frontiers in Neural Circuits, 2023 - frontiersin.org
The interconnected nuclei of the ventral basal ganglia have long been identified as key
regulators of motivated behavior, and dysfunction of this circuit is strongly implicated in …
regulators of motivated behavior, and dysfunction of this circuit is strongly implicated in …
The indirect pathway of the basal ganglia promotes transient punishment but not motor suppression
Optogenetic stimulation of Adora2a receptor-expressing spiny projection neurons (A2A-
SPNs) in the striatum drives locomotor suppression and transient punishment, results …
SPNs) in the striatum drives locomotor suppression and transient punishment, results …
Distributed dopaminergic signaling in the basal ganglia and its relationship to motor disability in Parkinson's disease
The degeneration of mesencephalic dopaminergic neurons that innervate the basal ganglia
is responsible for the cardinal motor symptoms of Parkinson's disease (PD). It has been …
is responsible for the cardinal motor symptoms of Parkinson's disease (PD). It has been …
[HTML][HTML] Virtual deep brain stimulation: Multiscale co-simulation of a spiking basal ganglia model and a whole-brain mean-field model with The Virtual Brain
JM Meier, D Perdikis, A Blickensdörfer… - Experimental …, 2022 - Elsevier
Deep brain stimulation (DBS) has been successfully applied in various neurodegenerative
diseases as an effective symptomatic treatment. However, its mechanisms of action within …
diseases as an effective symptomatic treatment. However, its mechanisms of action within …
Striatal direct pathway targets Npas1+ pallidal neurons
The classic basal ganglia circuit model asserts a complete segregation of the two striatal
output pathways. Empirical data argue that, in addition to indirect-pathway striatal projection …
output pathways. Empirical data argue that, in addition to indirect-pathway striatal projection …
A non-canonical striatopallidal Go pathway that supports motor control
In the classical model of the basal ganglia, direct pathway striatal projection neurons
(dSPNs) send projections to the substantia nigra (SNr) and entopeduncular nucleus to …
(dSPNs) send projections to the substantia nigra (SNr) and entopeduncular nucleus to …
Selective encoding of reward predictions and prediction errors by globus pallidus subpopulations
Basal ganglia (BG) circuits help guide and invigorate actions using predictions of future
rewards (values). Within the BG, the globus pallidus pars externa (GPe) may play an …
rewards (values). Within the BG, the globus pallidus pars externa (GPe) may play an …
Using deep learning to study emotional behavior in rodent models
JY Kuo, AJ Denman, NJ Beacher… - Frontiers in Behavioral …, 2022 - frontiersin.org
Quantifying emotional aspects of animal behavior (eg, anxiety, social interactions, reward,
and stress responses) is a major focus of neuroscience research. Because manual scoring …
and stress responses) is a major focus of neuroscience research. Because manual scoring …
Synaptic determinants of cholinergic interneurons hyperactivity during parkinsonism
M Padilla-Orozco, M Duhne… - Frontiers in Synaptic …, 2022 - frontiersin.org
Parkinson's disease is a neurodegenerative ailment generated by the loss of dopamine in
the basal ganglia, mainly in the striatum. The disease courses with increased striatal levels …
the basal ganglia, mainly in the striatum. The disease courses with increased striatal levels …