Rotors and the dynamics of cardiac fibrillation
SV Pandit, J Jalife - Circulation research, 2013 - Am Heart Assoc
The objective of this article is to present a broad review of the role of cardiac electric rotors
and their accompanying spiral waves in the mechanism of cardiac fibrillation. At the outset …
and their accompanying spiral waves in the mechanism of cardiac fibrillation. At the outset …
Nonlinear and stochastic dynamics in the heart
In a normal human life span, the heart beats about 2–3 billion times. Under diseased
conditions, a heart may lose its normal rhythm and degenerate suddenly into much faster …
conditions, a heart may lose its normal rhythm and degenerate suddenly into much faster …
Multiple mechanisms of spiral wave breakup in a model of cardiac electrical activity
It has become widely accepted that the most dangerous cardiac arrhythmias are due to
reentrant waves, ie, electrical wave (s) that recirculate repeatedly throughout the tissue at a …
reentrant waves, ie, electrical wave (s) that recirculate repeatedly throughout the tissue at a …
Mechanisms of wave fractionation at boundaries of high-frequency excitation in the posterior left atrium of the isolated sheep heart during atrial fibrillation
Background—High-frequency fractionated electrograms recorded during atrial fibrillation
(AF) in the posterior left atrium (PLA) and elsewhere are being used as target sites for …
(AF) in the posterior left atrium (PLA) and elsewhere are being used as target sites for …
The physics of heart rhythm disorders
WJ Rappel - Physics reports, 2022 - Elsevier
The global burden caused by cardiovascular disease is substantial, with heart disease
representing the most common cause of death around the world. There remains a need to …
representing the most common cause of death around the world. There remains a need to …
Visualization of spiral and scroll waves in simulated and experimental cardiac tissue
The heart is a nonlinear biological system that can exhibit complex electrical dynamics,
complete with period-doubling bifurcations and spiral and scroll waves that can lead to …
complete with period-doubling bifurcations and spiral and scroll waves that can lead to …
Role of calcium cycling versus restitution in the mechanism of repolarization alternans
EJ Pruvot, RP Katra, DS Rosenbaum… - Circulation …, 2004 - Am Heart Assoc
T-wave alternans, a powerful marker of arrhythmic events, results from alternation in action
potential duration (APD). The underlying cellular mechanism of APD alternans is unknown …
potential duration (APD). The underlying cellular mechanism of APD alternans is unknown …
Suppression of alternans and conduction blocks despite steep APD restitution: electrotonic, memory, and conduction velocity restitution effects
We examine the utility of the action potential (AP) duration (APD) restitution curve slope in
predicting the onset of electrical alternans when electrotonic and memory effects are …
predicting the onset of electrical alternans when electrotonic and memory effects are …
Effects of pacing site and stimulation history on alternans dynamics and the development of complex spatiotemporal patterns in cardiac tissue
Alternans of action potential duration has been associated with T wave alternans and the
development of arrhythmias because it produces large gradients of repolarization. However …
development of arrhythmias because it produces large gradients of repolarization. However …
Nonlinear physics of electrical wave propagation in the heart: a review
The beating of the heart is a synchronized contraction of muscle cells (myocytes) that is
triggered by a periodic sequence of electrical waves (action potentials) originating in the …
triggered by a periodic sequence of electrical waves (action potentials) originating in the …