Macrophages in heterotopic ossification: from mechanisms to therapy

Y Huang, X Wang, D Zhou, W Zhou, F Dai… - NPJ Regenerative …, 2021 - nature.com
Heterotopic ossification (HO) is the formation of extraskeletal bone in non-osseous tissues. It
is caused by an injury that stimulates abnormal tissue healing and regeneration, and …

Heterotopic ossification: clinical features, basic researches, and mechanical stimulations

Y Xu, M Huang, W He, C He, K Chen, J Hou… - Frontiers in cell and …, 2022 - frontiersin.org
Heterotopic ossification (HO) is defined as the occurrence of extraskeletal bone in soft
tissue. Although this pathological osteogenesis process involves the participation of …

[HTML][HTML] Momelotinib (JAK1/JAK2/ACVR1 inhibitor): mechanism of action, clinical trial reports, and therapeutic prospects beyond myelofibrosis

A Tefferi, A Pardanani, N Gangat - Haematologica, 2023 - ncbi.nlm.nih.gov
Janus kinase (JAK) 2 inhibitors are now part of the therapeutic armamentarium for primary
and secondary myelofibrosis (MF). Patients with MF endure shortened survival and poor …

Indomethacin for heterotopic ossification prophylaxis following surgical treatment of elbow trauma: A randomized controlled trial

Y Atwan, I Abdulla, R Grewal, KJ Faber… - Journal of Shoulder and …, 2023 - Elsevier
Background Heterotopic ossification is a frequent complication following surgical treatment
of elbow trauma. The use of indomethacin to prevent heterotopic ossification is reported in …

Heterotopic ossification in mice overexpressing Bmp2 in Tie2+ lineages

B Prados, R Del Toro, D MacGrogan… - Cell Death & …, 2021 - nature.com
Bone morphogenetic protein (Bmp) signaling is critical for organismal development and
homeostasis. To elucidate Bmp2 function in the vascular/hematopoietic lineages we …

Navigating the complex landscape of fibrodysplasia ossificans progressiva: from current paradigms to therapeutic frontiers

S Anwar, T Yokota - Genes, 2023 - mdpi.com
Fibrodysplasia ossificans progressiva (FOP) is an enigmatic, ultra-rare genetic disorder
characterized by progressive heterotopic ossification, wherein soft connective tissues …

Fibrodysplasia ossificans progressiva: a challenging diagnosis

D De Brasi, F Orlando, V Gaeta, M De Liso… - Genes, 2021 - mdpi.com
Fibrodysplasia ossificans progressiva (FOP) is an ultrarare genetic condition characterized
by extraskeletal bone formation. Most of the musculoskeletal characteristics of FOP are …

Palovarotene (Sohonos), a synthetic retinoid for reducing new heterotopic ossification in fibrodysplasia ossificans progressiva (FOP): history, present, and future

EC Hsiao, M Pacifici - JBMR plus, 2024 - academic.oup.com
Retinoids are metabolic derivatives of vitamin A and play crucial roles in the regulation of
various tissues and organs during prenatal and postnatal development. Active retinoids, like …

Development of an animal model for traumatic brain injury augmentation of heterotopic ossification in response to local injury

C Kesavan, GA Gomez, S Pourteymoor, S Mohan - Biomedicines, 2023 - mdpi.com
Heterotopic ossification (HO) is the abnormal growth of bone in soft connective tissues that
occurs as a frequent complication in individuals with traumatic brain injury (TBI) and in rare …

Challenges in the diagnosis of fibrodysplasia ossificans progressiva with the ACVR1 mutation (c.774G > C, p.R258S): a case report and review of literature

S Yang, R Cui, J Li, R Dai - Orphanet Journal of Rare Diseases, 2024 - Springer
The diagnosis of fibrodysplasia ossificans progressiva is missed or delayed because of its
insidious precursors, especially in uncharacteristic cases. Fibrodysplasia ossificans …