Cyclic dinucleotides (CDNs) are highly versatile signalling molecules that control various
important biological processes in bacteria. The best-studied example is cyclic di-GMP (c-di …

Lactic acid bacteria (LAB) are important starter, commensal, or pathogenic microorganisms.
The stress physiology of LAB has been studied in depth for over 2 decades, fueled mostly by …

The second messenger molecule cyclic di-AMP (c-di-AMP) is formed by many bacteria and
archaea. In many species that produce c-di-AMP, this second messenger is essential for …

Lipid metabolism has been associated with the cyclic guanosine monophosphate (GMP)-
AMP synthase (cGAS) stimulator of interferon genes (STING) DNA-sensing pathway, but our …

Cyclic di-adenosine monophosphate (c-di-AMP) is a broadly conserved second messenger
required for bacterial growth and infection. However, the molecular mechanisms of c-di-AMP …

The nucleotide cyclic di-3′, 5′-adenosine monophosphate (c-di-AMP) was recently
identified as an essential and widespread second messenger in bacterial signaling. Among …

ABSTRACT Manganese (Mn2+) is an essential trace element within organisms spanning
the entire tree of life. In this review, we provide an overview of Mn2+ transport and the …

Genetic interactions identify functional connections between genes and pathways,
establishing gene functions or druggable targets. Here we use CRISPRi–TnSeq, CRISPRi …

Cyclic di-AMP is a second-messenger nucleotide that is produced by many bacteria and
some archaea. Recent work has shown that c-di-AMP is unique among the signaling …

Cyclic di‐AMP (c‐di‐AMP) is an emerging second messenger in bacteria. It has been shown
to play important roles in bacterial fitness and virulence. However, transduction of c‐di‐AMP …