Estrogen and estrogen receptors mediate the mechanobiology of bone disease and repair

V Shi, EF Morgan - Bone, 2024 - Elsevier
It is well understood that the balance of bone formation and resorption is dependent on both
mechanical and biochemical factors. In addition to cell-secreted cytokines and growth …

Sexual dimorphism in the musculoskeletal system: sex hormones and beyond

LI Plotkin, A Bruzzaniti, R Pianeta - Journal of the Endocrine …, 2024 - academic.oup.com
Mounting evidence indicates that whereas some fundamental aspects of bone cell
differentiation and function are similar in females and males, there is a clear contribution of …

[HTML][HTML] High circulating concentrations of estradiol are anabolic for bone mass and strength in an adult male to female transgender mouse model

VS Venkatesh, T Nie, S Golub, KS Stok, H Hemmatian… - Bone, 2024 - Elsevier
The effects of gender affirming hormone therapy (GAHT) on bone microarchitecture and
fracture risk in adult transgender women is unclear. To investigate the concept that skeletal …

[HTML][HTML] Serum Uric Acid and Bone Health in Middle-Aged and Elderly Hypertensive Patients: A Potential U-Shaped Association and Implications for Future Fracture …

S Song, X Cai, J Hu, Q Zhu, D Shen, H Ma, Y Zhang… - Metabolites, 2025 - mdpi.com
Background: The influence of serum uric acid (SUA) on bone metabolism, as suggested by
previous studies, remains a contentious issue. SUA plays a complex role in bone health and …

[HTML][HTML] Antioxidant 1, 2, 3, 4, 6-Penta-O-galloyl-β-D-glucose Alleviating Apoptosis and Promoting Bone Formation Is Associated with Estrogen Receptors

Y Hua, H Wang, T Chen, Y Zhou, Z Chen, X Zhao… - …, 2024 - pmc.ncbi.nlm.nih.gov
1, 2, 3, 4, 6-penta-O-galloyl-β-D-glucose (PGG) is the main phenolic active ingredient in
Paeoniae Radix Alba, which is commonly used for the treatment of osteoporosis (OP). PGG …

Inverted U-shaped association between total testosterone with bone mineral density in men over 60 years old

J Ma, J Zhao, N Wu, M Han, Z Yang, H Chen… - BMC Endocrine …, 2024 - Springer
Background Aging often leads to changes in hormone levels, particularly testosterone,
which is thought to significantly affect bone health in older males. Objective This study aimed …

[HTML][HTML] Investigating the mechanical properties of cortical bone under dynamic torsional loading

J Lei, Z Li, H Su, S Li, Z Liu - Theoretical and Applied Mechanics Letters, 2024 - Elsevier
Bone is a multi-phase, non-homogeneous material that exhibits strain rate sensitivity, and it
may fail under compression, tension, torsion, or a combination of these loading. The …