[HTML][HTML] T cell-engaging bispecific antibodies targeting gp100 and PRAME: expanding application from uveal melanoma to cutaneous melanoma

R Reschke, AH Enk, JC Hassel - Pharmaceutics, 2024 - mdpi.com
Uveal melanoma represents a rare and aggressive subtype of melanoma with limited
treatment options and poor prognosis, especially in the metastatic setting. Tebentafusp, a …

[HTML][HTML] Measurable residual disease testing in multiple myeloma following T-cell redirecting therapies

KG Shim, R Fonseca - Cancers, 2024 - mdpi.com
Simple Summary Multiple myeloma (MM) is a blood cancer which classically has a
prolonged course of remissions and relapses. Several new highly efficacious medications …

Endothelial injury and dysfunction with emerging immunotherapies in multiple myeloma, the impact of COVID-19, and endothelial protection with a focus on the …

CC Mo, E Richardson, E Calabretta, F Corrado… - Blood Reviews, 2024 - Elsevier
Patients with multiple myeloma (MM) were among the groups impacted more severely by the
COVID-19 pandemic, with higher rates of severe disease and COVID-19-related mortality …

Multiple mechanisms contribute to acquired TRAIL resistance in multiple myeloma

FV Ticona-Pérez, X Chen, A Pandiella… - Cancer Cell …, 2024 - Springer
Multiple Myeloma (MM) prognosis has recently improved thanks to the incorporation of new
therapies to the clinic. Nonetheless, it is still a non-curable malignancy. Targeting cancer …

T-Cell redirecting bispecific antibodies: a review of a novel class of immuno-oncology for advanced prostate cancer

J Palecki, A Bhasin, A Bernstein, PJ Mille… - Cancer Biology & …, 2024 - Taylor & Francis
Novel T-cell immunotherapies such as bispecific T-cell engagers (BiTEs) are emerging as
promising therapeutic strategies for prostate cancer. BiTEs are engineered bispecific …

The EMMY longitudinal, cohort study: real-world data to describe multiple myeloma management and outcomes as more therapeutic options emerge

O Decaux, R Garlantézec… - Clinical Hematology …, 2024 - pmc.ncbi.nlm.nih.gov
The therapeutic management of patients with multiple myeloma (MM) is complex. Despite
substantial advances, MM remains incurable, and management involves cycles of treatment …

An immunocompetent model to uncover the secrets of bispecifics

JE Maakaron - Blood Advances, 2024 - ashpublications.org
In this issue of Blood Advances, Long et al 1 describe a novel mouse model with humanized
CD3 that makes it ideal for studying bispecific antibodies (BsAbs). The authors provide proof …

A phase 1b/2 study evaluating efficacy and safety of MP0250, a designed ankyrin repeat protein (DARPin) simultaneously targeting vascular endothelial growth factor …

S Knop, M Szarejko, N Grząśko, S Bringhen… - …, 2024 - Wiley Online Library
MP0250 is a designed ankyrin repeat protein that specifically inhibits both vascular
endothelial growth factor A (VEGF‐A) and hepatocyte growth factor (HGF), aiming at …

Cytokine Release Syndrome Associated With Immune‐Modulating Chemotherapy: Potential Mitigating Role of Intravenous Omega‐3 Fatty Acid Triglycerides

DF Driscoll, BR Bistrian - Cancer Reports, 2024 - Wiley Online Library
Background Patient susceptibility to cytokine release syndrome (CRS) resulting from
immune‐modulating chemotherapy has profound implications for clinical outcome. This is …

Therapy with mosunetuzumab, a bispecific antibody for relapsed/refractory hairy cell leukemia

T Tadmor, I Levy Yurkovski - Leukemia & Lymphoma, 2024 - Taylor & Francis
Classical hairy-cell leukemia (chCL) is a rare chronic B-cell leukemia, more frequent in
middle-aged males [1, 2]. the diagnosis is based on bone marrow examination which …