A systemic view of Alzheimer disease—insights from amyloid-β metabolism beyond the brain

J Wang, BJ Gu, CL Masters, YJ Wang - Nature reviews neurology, 2017 - nature.com
Alzheimer disease (AD) is the most common type of dementia, and is currently incurable;
existing treatments for AD produce only a modest amelioration of symptoms. Research into …

Potential fluid biomarkers for the diagnosis of mild cognitive impairment

VV Giau, E Bagyinszky, SSA An - International journal of molecular …, 2019 - mdpi.com
Mild cognitive impairment (MCI) is characterized by a level of cognitive impairment that is
lower than normal for a person's age, but a higher function than that that observed in a …

Profiles of extracellular miRNA in cerebrospinal fluid and serum from patients with Alzheimer's and Parkinson's diseases correlate with disease status and features of …

K Burgos, I Malenica, R Metpally, A Courtright… - PloS one, 2014 - journals.plos.org
The discovery and reliable detection of markers for neurodegenerative diseases have been
complicated by the inaccessibility of the diseased tissue-such as the inability to biopsy or …

Air pollution and children: neural and tight junction antibodies and combustion metals, the role of barrier breakdown and brain immunity in neurodegeneration

L Calderón-Garcidueñas, A Vojdani… - Journal of …, 2014 - journals.sagepub.com
Millions of children are exposed to concentrations of air pollutants, including fine particulate
matter (PM2. 5), above safety standards. In the Mexico City Metropolitan Area (MCMA) …

High prevalence of NMDA receptor IgA/IgM antibodies in different dementia types

S Doss, KP Wandinger, BT Hyman… - Annals of clinical …, 2014 - Wiley Online Library
Objective To retrospectively determine the frequency of N‐Methyl‐D‐Aspartate (NMDA)
receptor (NMDAR) autoantibodies in patients with different forms of dementia. Methods …

Immune regulatory functions of macrophages and microglia in central nervous system diseases

M Poppell, G Hammel, Y Ren - International Journal of Molecular …, 2023 - mdpi.com
Macrophages can be characterized as a very multifunctional cell type with a spectrum of
phenotypes and functions being observed spatially and temporally in various disease states …

[HTML][HTML] Autoantibodies in Alzheimer's disease: potential biomarkers, pathogenic roles, and therapeutic implications

J Wu, L Li - Journal of biomedical research, 2016 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a prevalent and debilitating neurodegenerative disorder in the
elderly. The etiology of AD has not been fully defined and currently there is no cure for this …

Specialized roles of neurofilament proteins in synapses: Relevance to neuropsychiatric disorders

A Yuan, RA Nixon - Brain research bulletin, 2016 - Elsevier
Neurofilaments are uniquely complex among classes of intermediate filaments in being
composed of four subunits (NFL, NFM, NFH and alpha-internexin in the CNS) that differ in …

Review on intermediate filaments of the nervous system and their pathological alterations

C Lépinoux-Chambaud, J Eyer - Histochemistry and cell biology, 2013 - Springer
Intermediate filaments (IFs) of the nervous system, including neurofilaments, α-internexin,
glial fibrillary acidic protein, synemin, nestin, peripherin and vimentin, are finely expressed …

[HTML][HTML] Autoantibodies targeting neuronal proteins as biomarkers for neurodegenerative diseases

G Kocurova, J Ricny, SV Ovsepian - Theranostics, 2022 - ncbi.nlm.nih.gov
Neurodegenerative diseases (NDDs) are associated with the accumulation of a range of
misfolded proteins across the central nervous system and related autoimmune responses …