Chitin and chitosan: prospective biomedical applications in drug delivery, cancer treatment, and wound healing

P Baharlouei, A Rahman - Marine Drugs, 2022 - mdpi.com
Chitin and its derivative chitosan are highly abundant polymers in nature, appearing in both
the shells and exoskeletons of various marine and non-marine species. Since they possess …

The role of oxidative stress and its counteractive utility in colorectal cancer (CRC)

D Basak, MN Uddin, J Hancock - Cancers, 2020 - mdpi.com
Simple Summary Colorectal cancer (CRC) is very common throughout the world. Despite an
improved outcome with the current treatment regimen, a huge number of patients relapse …

Curcumin and colorectal cancer: from basic to clinical evidences

M Pricci, B Girardi, F Giorgio, G Losurdo… - International journal of …, 2020 - mdpi.com
Curcumin diffuses through cell membranes into the endoplasmic reticulum, mitochondria,
and nucleus, where it exerts actions, as an antioxidant property. Therefore, its use has been …

Free radicals as a double-edged sword: The cancer preventive and therapeutic roles of curcumin

N Gupta, K Verma, S Nalla, A Kulshreshtha, R Lall… - Molecules, 2020 - mdpi.com
Free radicals, generally composed of reactive oxygen species (ROS) and reactive nitrogen
species (RNS), are generated in the body by various endogenous and exogenous systems …

Curcumin in cancer therapy: Exploring molecular mechanisms and overcoming clinical challenges

W Wang, M Li, L Wang, L Chen, BC Goh - Cancer Letters, 2023 - Elsevier
Cancer poses a significant global health burden, necessitating the widespread use of
chemotherapy and radiotherapy as conventional frontline interventions. Although targeted …

Mechanism of apoptosis induced by curcumin in colorectal cancer

NI Ismail, I Othman, F Abas, N H. Lajis… - International journal of …, 2019 - mdpi.com
Colorectal cancer (CRC) is among the top three cancer with higher incident and mortality
rate worldwide. It is estimated that about over than 1.1 million of death and 2.2 million new …

Plant-derived natural products in cancer research: extraction, mechanism of action, and drug formulation

WH Talib, I Alsalahat, S Daoud, RF Abutayeh… - Molecules, 2020 - mdpi.com
Cancer is one of the main causes of death globally and considered as a major challenge for
the public health system. The high toxicity and the lack of selectivity of conventional …

Targeting of cancer cell death mechanisms by curcumin: implications to cancer therapy

C Yu, B Yang, M Najafi - Basic & clinical pharmacology & …, 2021 - Wiley Online Library
Cancer is known as a second major cause of death globally. Nowadays, several modalities
have been developed for the treatment of cancer. Radiotherapy and chemotherapy are the …

Curcumin reverses NNMT-induced 5-fluorouracil resistance via increasing ROS and cell cycle arrest in colorectal cancer cells

G Li, S Fang, X Shao, Y Li, Q Tong, B Kong, L Chen… - Biomolecules, 2021 - mdpi.com
Nicotinamide N-methyltransferase (NNMT) plays multiple roles in improving the
aggressiveness of colorectal cancer (CRC) and enhancing resistance to 5-Fluorouracil (5 …

Targeting copper metabolism: a promising strategy for cancer treatment

R Kong, G Sun - Frontiers in Pharmacology, 2023 - frontiersin.org
Copper is an essential micronutrient that plays a critical role in many physiological
processes. However, excessive copper accumulation in cancer cells has been linked to …