Role of the autonomic nervous system in atrial fibrillation: pathophysiology and therapy

PS Chen, LS Chen, MC Fishbein, SF Lin… - Circulation …, 2014 - Am Heart Assoc
Autonomic nervous system activation can induce significant and heterogeneous changes of
atrial electrophysiology and induce atrial tachyarrhythmias, including atrial tachycardia and …

The autonomic nervous system and heart failure

VG Florea, JN Cohn - Circulation research, 2014 - Am Heart Assoc
The pathophysiology of heart failure (HF) is characterized by hemodynamic abnormalities
that result in neurohormonal activation and autonomic imbalance with increase in …

Heart failure with preserved ejection fraction: mechanisms, clinical features, and therapies

K Sharma, DA Kass - Circulation research, 2014 - Am Heart Assoc
The clinical syndrome comprising heart failure (HF) symptoms but with a left ventricular
ejection fraction (EF) that is not diminished, eg, HF with preserved EF, is increasingly the …

New approaches in the treatment of hypertension

S Oparil, RE Schmieder - Circulation research, 2015 - Am Heart Assoc
Hypertension is the most common modifiable risk factor for cardiovascular disease and
death, and lowering blood pressure with antihypertensive drugs reduces target organ …

Baroreflex activation therapy lowers blood pressure in patients with resistant hypertension: results from the double-blind, randomized, placebo-controlled rheos pivotal …

JD Bisognano, G Bakris, MK Nadim, L Sanchez… - Journal of the American …, 2011 - jacc.org
Objectives: We sought to determine the effect of baroreflex activation therapy (BAT) on
systolic blood pressure (SBP) in patients with resistant hypertension. Background: The …

Minimally invasive system for baroreflex activation therapy chronically lowers blood pressure with pacemaker-like safety profile: results from the Barostim neo trial

UC Hoppe, MC Brandt, R Wachter, J Beige… - Journal of the American …, 2012 - Elsevier
BACKGROUND: Previous trials have demonstrated clinically significant and durable
reductions in arterial pressure from baroreflex activation therapy (BAT), resulting from …

The sympathetic nervous system and blood pressure in humans: implications for hypertension

JP Fisher, JFR Paton - Journal of human hypertension, 2012 - nature.com
A neurogenic component to primary hypertension (hypertension) is now well established.
Along with raised vasomotor tone and increased cardiac output, the chronic activation of the …

Measuring, analyzing, and managing drug adherence in resistant hypertension

M Burnier, G Wuerzner, H Struijker-Boudier… - …, 2013 - Am Heart Assoc
One of the main reasons why drug adherence remains generally ignored, outside of clinical
trials and prospective surveys, is the lack of reliable, easy to use, and economical methods …

Novel mechanisms in the pathogenesis of atrial fibrillation: practical applications

DH Lau, U Schotten, R Mahajan, NA Antic… - European heart …, 2016 - academic.oup.com
Intensive research over the last few decades has seen significant advances in our
understanding of the complex mechanisms underlying atrial fibrillation (AF). The epidemic of …

Device-based therapies for arterial hypertension

L Lauder, M Azizi, AJ Kirtane, M Boehm… - Nature Reviews …, 2020 - nature.com
Arterial hypertension is the most prevalent modifiable risk factor associated with
cardiovascular morbidity and mortality. Although antihypertensive drugs are widely …