Bispecific antibodies (bsAbs) are antibodies that bind two distinct epitopes to cancer.. For
use in oncology, one bsAb has been approved and 57 bsAbs are in clinical trials, none of …

The function of antibodies (Abs) involves specific binding to antigens (Ags) and activation of
other components of the immune system to fight pathogens. The six hypervariable loops …

Mucins (MUC) protect epithelial barriers from environmental insult to maintain homeostasis.
However, their aberrant overexpression and glycosylation in various malignancies facilitate …

The global antibody market has grown exponentially due to increasing applications in
research, diagnostics and therapy. Antibodies are present in complex matrices (eg serum …

Recombinant antibodies, including whole antibodies, antibody fragments, antibody fusion
proteins or conjugates, and more recently also small antibody mimetics, have found …

Thanks to their potential to bind virtually all types of molecules; monoclonal antibodies are in
increasing demand as therapeutics and diagnostics. To overcome the overloading of current …

Rational engineering methods can be applied with reasonable success to optimize
physicochemical characteristics of proteins, in particular, antibodies. Here, we describe a …

Over the last four decades, molecular cloning has evolved tremendously. Efficient products
allowing assembly of multiple DNA fragments have become available. However, cost …

High‐precision tumor targeting with conventional therapeutics is based on the concept of the
ideal drug as a “magic bullet”; this became possible after techniques were developed for …

Fusion of small recombinant antibody fragments to an albumin-binding domain (ABD) from
streptococcal protein G strongly extends their plasma half-life. This ABD binds with …