The neurotransmitters GABA and glycine mediate fast synaptic inhibition by activating ligand-
gated chloride channels—namely, type A GABA (GABAA) and glycine receptors. Both types …

Synapses are specialized cell–cell contacts that mediate communication between neurons.
Most excitatory synapses in the brain are housed on dendritic spines, small actin-rich …

In the mammalian CNS, each neuron typically receives thousands of synaptic inputs from
diverse classes of neurons. Synaptic transmission to the postsynaptic neuron relies on …

GABAA receptors (GABAAR s) are ligand‐gated Cl− channels that mediate most of the fast
inhibitory neurotransmission in the central nervous system (CNS). Multiple GABAAR …

Gephyrin is a central element that anchors, clusters and stabilizes glycine and γ-
aminobutyric acid type A receptors at inhibitory synapses of the mammalian brain. It self …

Non‐Technical Summary To be effective, synaptic transmission requires precise alignment
of the presynaptic terminal, releasing the neurotransmitter, with the postsynaptic density …

Gephyrin and collybistin are key components of GABA A receptor (GABA AR) clustering.
Nonetheless, resolving the molecular interactions between the plethora of GABA AR …

γ-aminobutyric acid type A (GABAA) receptors play an important role in mediating fast
synaptic inhibition in the brain. They are ubiquitously expressed in the CNS and also …

In the brain, many types of interneurons make functionally diverse inhibitory synapses onto
principal neurons. Although numerous molecules have been identified to function in …

Fast inhibitory synaptic transmission is mediated by γ-aminobutyric acid type A receptors
(GABAARs) that are enriched at functionally diverse synapses via mechanisms that remain …