Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) of the phenylacetic acid class
with anti-inflammatory, analgesic, and antipyretic properties. Contrary to the action of many …

Background Biorelevant media for evaluation of dosage form performance in the
gastrointestinal lumen were first introduced in the late 1990s. Since then, a variety of …

Background The purpose of this study was to compare the efficacy and safety of curcumin
with those of diclofenac in the treatment of knee osteoarthritis (OA). Methods In this …

The focus of the current investigations was to apply quality by design (QbD) approach to the
development of dispersible tablets. Critical material and process parameters are linked to …

Literature and new experimental data relevant to the decision to allow a waiver of in vivo
bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage …

To enable more precise prediction of oral drug absorption, an existing physiologically based
absorption model was revised. The revised model reflects detailed knowledge of human …

In vitro biorelevant dissolution tests enabling the prediction of in vivo performance of an oral
modified-release (MR) dosage form were developed in this study. In vitro dissolution of MR …

The major challenge of the pharmaceutical industry is to find potential solvents for poorly
water-soluble drug molecules. Ionic liquids (ILs) have attracted this industry as (co-) solvents …

During the last decades, the study of the in vitro dissolution of pharmaceuticals has been
strongly encouraged by the FDA in order to determine its relationship with the in vivo …

Literature and experimental data relevant to the decision to allow a waiver of in vivo
bioequivalence (BE) testing for the approval of immediate‐release (IR) solid oral dosage …