Background: Spontaneous deep intracerebral hemorrhage (ICH) is a devastating subtype of
stroke without specific treatments. It has been thought that smooth muscle cell (SMC) …

Treating retinal diseases to prevent sight loss is an increasingly important challenge. Thanks
to the configuration of the eye, the retina can be examined relatively easily in situ. Owing to …

Retinal hemodynamics and biomechanics play a significant role in understanding the
pathophysiology of several ocular diseases. However, these parameters are significantly …

The microcirculation plays a major role in maintaining homeostasis in the body. Alterations
or dysfunctions of the microcirculation can lead to several types of serious diseases. It is not …

In this paper we study from a mathematical point of view the drug release and the
degradation process in the context of biodegradable intravitreal implants. In particular, two …

Autoregulation is a mechanism necessary to maintain an approximately constant blood flow
rate in the microcirculation when acute changes in systemic pressure occur. Failure of …

Microvessels–blood vessels with diameter less than 200 μ m–form large intricate networks,
functionally organized into arterioles, capillaries and venules. In these networks, the …

In this work, a novel fluid–structure interaction algorithm for the simulation of blood flow in
three-dimensional deformable vessels is addressed. The method extends the mid-fidelity …

The structure of the eye offers a unique opportunity to directly observe the microcirculation,
by means, for instance, of fundus camera, which are cheap devices commonly used in the …

Analytical solutions to Fluid-Structure Interaction (FSI) problems are almost absent in the
literature. How-ever, they are not only essential for understanding the intricate coupling …