Functional amyloids

D Otzen, R Riek - Cold Spring Harbor perspectives in …, 2019 - cshperspectives.cshlp.org
When protein/peptides aggregate, they usually form the amyloid state consisting of cross β-
sheet structure built by repetitively stacked β-strands forming long fibrils. Amyloids are …

Two decades of studying functional amyloids in microorganisms

SA Levkovich, E Gazit, DL Bar-Yosef - Trends in Microbiology, 2021 - cell.com
In the past two decades, amyloids, typically associated with human diseases, have been
described to play various functional roles in nearly all life forms. The structural and functional …

[HTML][HTML] Functional amyloid and other protein fibers in the biofilm matrix

E Erskine, CE MacPhee, NR Stanley-Wall - Journal of Molecular Biology, 2018 - Elsevier
Biofilms are ubiquitous in the natural and man-made environment. They are defined as
microbes that are encapsulated in an extracellular, self-produced, biofilm matrix. Growing …

Functional amyloids: Where supramolecular amyloid assembly controls biological activity or generates new functionality

JA Buchanan, NR Varghese, CL Johnston… - Journal of Molecular …, 2023 - Elsevier
Functional amyloids are a rapidly expanding class of fibrillar protein structures, with a core
cross-β scaffold, where novel and advantageous biological function is generated by the …

A comprehensive review of protein misfolding disorders, underlying mechanism, clinical diagnosis, and therapeutic strategies

S Basha, DC Mukunda, J Rodrigues… - Ageing Research …, 2023 - Elsevier
Introduction The most prevalent biological macromolecules in living systems are proteins,
the building block of life, extremely dynamic in structure and functions. Due to several …

Microbial hitchhiking: how Streptomyces spores are transported by motile soil bacteria

AR Muok, D Claessen, A Briegel - The ISME journal, 2021 - academic.oup.com
Streptomycetes are sessile bacteria that produce metabolites that impact the behavior of
microbial communities. Emerging studies have demonstrated that Streptomyces spores are …

Stress-induced adaptive morphogenesis in bacteria

E Ultee, K Ramijan, RT Dame, A Briegel… - Advances in microbial …, 2019 - Elsevier
Bacteria thrive in virtually all environments. Like all other living organisms, bacteria may
encounter various types of stresses, to which cells need to adapt. In this chapter, we …

Importance of microbial amphiphiles: interaction potential of biosurfactants, amyloids, and other exo-polymeric-substances

NG Master, AR Markande - World Journal of Microbiology and …, 2023 - Springer
Microorganisms produce a diverse group of biomolecules having amphipathic nature
(amphiphiles). Microbial amphiphiles, including amyloids, bio-surfactants, and other exo …

Anti-biofilm molecules targeting functional amyloids

L Matilla-Cuenca, A Toledo-Arana, J Valle - Antibiotics, 2021 - mdpi.com
The choice of an effective therapeutic strategy in the treatment of biofilm-related infections is
a significant issue. Amyloids, which have been historically related to human diseases, are …

The amyloid state of proteins: A boon or bane?

MN Hassan, F Nabi, AN Khan, M Hussain… - International Journal of …, 2022 - Elsevier
Proteins and their aggregation is significant field of research due to their association with
various conformational maladies including well-known neurodegenerative diseases like …