Due to improved health care, diet and infrastructure in developed countries, since 1840 life
expectancy has increased by approximately 2 years per decade. Accordingly, by 2050, a …

Rapamycin, a macrocyclic lactone, is a highly specific inhibitor of the serine/threonine
protein kinase target of rapamycin (TOR). Although it is clear that TOR controls initiation of …

Eukaryotic messenger RNAs contain a modified guanosine, termed a cap, at their 5′ ends.
Translation of mRNAs requires the binding of an initiation factor, eIF4E, to the cap structure …

MALAT1 is a long noncoding RNA known to be misregulated in many human cancers. We
have identified a highly conserved small RNA of 61 nucleotides originating from the …

The 5′ mRNA cap structure is essential for efficient gene expression from yeast to human. It
plays a critical role in all aspects of the life cycle of an mRNA molecule. Capping occurs co …

Multiple mechanisms have evolved to regulate the eukaryotic genome. We have identified
CTN-RNA, a mouse tissue-specific∼ 8 kb nuclear-retained poly (A)+ RNA that regulates the …

Mnk1 and Mnk2 are protein kinases that are directly phosphorylated and activated by
extracellular signal-regulated kinase (ERK) or p38 mitogen-activated protein (MAP) kinases …

Dysregulation of Hippo pathway leads to hyperactivation of YAP-TEAD transcriptional
complex in various cancers, including colorectal cancer (CRC). In this study, we observed …

The eukaryotic translation initiation factor eIF4E is elevated in 30% of malignancies
including M4/M5 subtypes of acute myeloid leukemia (AML). The oncogenic potential of …

This study demonstrates that the eukaryotic translation initiation factor eIF4E is a critical
node in an RNA regulon that impacts nearly every stage of cell cycle progression …