Rapamycin, a macrocyclic lactone, is a highly specific inhibitor of the serine/threonine protein kinase target of rapamycin (TOR). Although it is clear that TOR controls initiation of …
JD Richter, N Sonenberg - Nature, 2005 - nature.com
Eukaryotic messenger RNAs contain a modified guanosine, termed a cap, at their 5′ ends. Translation of mRNAs requires the binding of an initiation factor, eIF4E, to the cap structure …
MALAT1 is a long noncoding RNA known to be misregulated in many human cancers. We have identified a highly conserved small RNA of 61 nucleotides originating from the …
I Topisirovic, YV Svitkin, N Sonenberg… - Wiley Interdisciplinary …, 2011 - Wiley Online Library
The 5′ mRNA cap structure is essential for efficient gene expression from yeast to human. It plays a critical role in all aspects of the life cycle of an mRNA molecule. Capping occurs co …
Multiple mechanisms have evolved to regulate the eukaryotic genome. We have identified CTN-RNA, a mouse tissue-specific∼ 8 kb nuclear-retained poly (A)+ RNA that regulates the …
T Ueda, R Watanabe-Fukunaga… - … and cellular biology, 2004 - Taylor & Francis
Mnk1 and Mnk2 are protein kinases that are directly phosphorylated and activated by extracellular signal-regulated kinase (ERK) or p38 mitogen-activated protein (MAP) kinases …
Y Guo, Z Zhu, Z Huang, L Cui, W Yu, W Hong… - Nature …, 2022 - nature.com
Dysregulation of Hippo pathway leads to hyperactivation of YAP-TEAD transcriptional complex in various cancers, including colorectal cancer (CRC). In this study, we observed …
The eukaryotic translation initiation factor eIF4E is elevated in 30% of malignancies including M4/M5 subtypes of acute myeloid leukemia (AML). The oncogenic potential of …
This study demonstrates that the eukaryotic translation initiation factor eIF4E is a critical node in an RNA regulon that impacts nearly every stage of cell cycle progression …