Introduction• Intracellular pH regulation controls energy balance and cell proliferation:
chemical and biological proof of principle‐Chemical proof of principle‐Biological proof of …

Cancer cells can adapt to low energy sources in the face of ATP depletion as well as to their
high levels of ROS by altering their metabolism and energy production networks which might …

Carbonic anhydrase IX (CAIX) is a hypoxia-inducible enzyme that is overexpressed by
cancer cells from many tumor types, and is a component of the pH regulatory system …

Current drug development in oncology is non-selective as it typically focuses on pathways
essential for the survival of all dividing cells. The unique metabolic profile of cancer, which is …

When cells sense a decrease in oxygen availability (hypoxia), they develop adaptive
responses in order to sustain this condition and survive. If hypoxia lasts too long or is too …

Right ventricular (RV) failure is an important clinical problem with no available therapies,
largely because its molecular mechanisms are unknown. Mitochondrial remodeling resulting …

The eukaryote's mitochondrial network is perhaps the cell's most sophisticated and dynamic
responsive sensing system. Integrating metabolic, oxygen, or danger signals with inputs …

Hypoxia inducible factor-1 (HIF-1) is as a key transcriptional mediator of the hypoxic
response in eukaryotic cells, regulating the expression of a myriad of genes involved in …

The p53 tumor suppressor protein has long been recognized as the central factor protecting
humans from cancer. It has been famously dubbed “the guardian of the genome” due to its …

Metastatic melanoma remained for decades without any effective treatment and was thus
considered as a paradigm of cancer resistance. Recent progress with understanding of the …