Protein SUMOylation is a major post-translational modification essential for maintaining
cellular homeostasis. SUMOylation has long been associated with stress responses as a …

Conjugation with the small ubiquitin-like modifier (SUMO) constitutes a key post-
translational modification regulating the stability, activity, and subcellular localization of its …

Stress is unavoidable and essential to cellular and organismal evolution and failure to adapt
or restore homeostasis can lead to severe diseases or even death. At the cellular level …

Background Ischemia/reperfusion injury impairs proteostasis, and triggers adaptive cellular
responses, such as the unfolded protein response (UPR), which functions to restore …

The underlying etiologies of seizures are highly heterogeneous and remain incompletely
understood. While studying the unfolded protein response (UPR) pathways in the brain, we …

Katanin p60 ATPase-containing subunit A1 (KATNA1) is a microtubule-cleaving enzyme that
regulates the development of neural protrusions through cytoskeletal rearrangements …

Background. The depressive symptom hallmarks the progression of the neurodegenerative
diseases, especially Alzheimer's disease. Bacterial infection is related to inflammation and …

SUMOylation is a post-translational modification that attaches a small ubiquitin-like modifier
(SUMO) group to a target protein via SUMO ligases, while deSUMOylation refers to the …

Objectives Recent evidence indicates that hippocampus is important for conditioned fear
memory (CFM). Though few studies consider the roles of various cell types' contribution to …

Traumatic brain injury (TBI) represents a main public health concern during the past decade,
attracting considerable interest because of its rising prevalence, wide-ranging risk factors …