Repeated exposure to drugs of abuse enhances the motor-stimulant response to these
drugs, a phenomenon termed behavioral sensitization. Animals that are extinguished from …

Amphetamine and substituted amphetamines, including methamphetamine,
methylphenidate (Ritalin), methylenedioxymethamphetamine (ecstasy), and the herbs khat …

The fundamental principle that unites addictive drugs appears to be that each enhances
synaptic dopamine by means that dissociate it from normal behavioral control, so that they …

Rationale and objectives: Repeated exposure to many drugs of abuse results in a
progressive and enduring enhancement in the motor stimulant effect elicited by a …

The relative contributions of glutamate and dopamine within the nucleus accumbens to
cocaine-induced reinstatement of drug-seeking behavior were assessed. When …

Repeated exposure to psychostimulants such as cocaine and amphetamine produces
behavioral sensitization, which is characterized by an augmented locomotor response to a …

Epidemiological data demonstrate that while women report lower rates of drug use than
men, the number of current drug users and abusers who are women continues to increase …

Examines the hypothesis that negative affective states can contribute to the reinforcement
associated with drug taking by changing the set point for hedonic processing or the set point …

Amphetamine (AMPH) inhibits uptake and causes release of dopamine (DA) from
presynaptic terminals. AMPH can act on both vesicular storage of DA and directly on the …

Psychostimulant drugs like amphetamine are readily self-administered by humans and
laboratory animals by virtue of their actions on dopamine (DA) neurons in the midbrain …