The α-synuclein origin and connectome model (SOC Model) of Parkinson's disease: explaining motor asymmetry, non-motor phenotypes, and cognitive decline

P Borghammer - Journal of Parkinson's disease, 2021 - content.iospress.com
A new model of Parkinson's disease (PD) pathogenesis is proposed, the α-Synuclein Origin
site and Connectome (SOC) model, incorporating two aspects of α-synuclein pathobiology …

Vestibular functions and Parkinson's disease

PF Smith - Frontiers in neurology, 2018 - frontiersin.org
For decades it has been speculated that Parkinson's Disease (PD) is associated with
dysfunction of the vestibular system, especially given that postural instability is one of the …

Older adults and individuals with Parkinson's disease control posture along suborthogonal directions that deviate from the traditional anteroposterior and mediolateral …

M Mangalam, DG Kelty-Stephen, I Seleznov… - Scientific Reports, 2024 - nature.com
A rich and complex temporal structure of variability in postural sway characterizes healthy
and adaptable postural control. However, neurodegenerative disorders such as Parkinson's …

Vestibular deficits in neurodegenerative disorders: balance, dizziness, and spatial disorientation

T Cronin, Q Arshad, BM Seemungal - Frontiers in neurology, 2017 - frontiersin.org
The vestibular system consists of the peripheral vestibular organs in the inner ear and the
associated extensive central nervous system projections—from the cerebellum and …

Auditory dysfunction in Parkinson's disease

Z Jafari, BE Kolb, MH Mohajerani - Movement Disorders, 2020 - Wiley Online Library
PD is a progressive and complex neurological disorder with heterogeneous
symptomatology. PD is characterized by classical motor features of parkinsonism and …

Hearing loss in neurological disorders

S Li, C Cheng, L Lu, X Ma, X Zhang, A Li… - Frontiers in cell and …, 2021 - frontiersin.org
Sensorineural hearing loss (SNHL) affects approximately 466 million people worldwide,
which is projected to reach 900 million by 2050. Its histological characteristics are lesions in …

The contributions of vestibular evoked myogenic potentials and acoustic vestibular stimulation to our understanding of the vestibular system

SM Rosengren, JG Colebatch - Frontiers in neurology, 2018 - frontiersin.org
Vestibular-evoked myogenic potentials (VEMPs) are short-latency muscle reflexes typically
recorded from the neck or eye muscles with surface electrodes. They are used clinically to …

Self‐motion perception in Parkinson's disease

O Halperin, S Israeli‐Korn… - European journal of …, 2021 - Wiley Online Library
Abstract Parkinson's disease (PD), best characterized by its classic motor symptoms, also
manifests non‐motor symptoms including perceptual impairments. Normal motor and …

Association between hearing sensitivity and dopamine transporter availability in Parkinson's disease

E Garasto, A Stefani, M Pierantozzi… - Brain …, 2023 - academic.oup.com
In a previous study, we observed:(i) significant hearing function impairment, assessed with
pure tone audiometry and distortion product otoacoustic emissions, in patients with …

The role of vestibular evoked myogenic potentials in multiple sclerosis-related vertigo. A systematic review of the literature

A Di Stadio, L Dipietro, M Ralli, A Greco, G Ricci… - Multiple sclerosis and …, 2019 - Elsevier
Background Vertigo is a common symptom of multiple sclerosis (MS) that can be caused by
a central or peripheral involvement of the vestibular pathways. Magnetic Resonance …