Solid-state nuclear magnetic resonance (ssNMR) spectroscopy enables the structural
characterization of a diverse array of biological assemblies that include amyloid fibrils, non …

Since the discovery of the mechanosensitive Piezo1 channel in 2010, there has been a
significant amount of research conducted to explore its regulatory role in the physiology and …

Water is essential for protein folding and assembly of amyloid fibrils. Internal water cavities
have been proposed for several amyloid fibrils, but no direct structural and dynamical data …

Phase-separated protein accumulation through the formation of several aggregate species
is linked to the pathology of several human disorders and diseases. Our current …

The swift rise in acceptance of molecular principles defining phase separation by a broad
array of scientific disciplines is shadowed by increasing discoveries linking phase …

Solution NMR is a key tool to study intrinsically disordered proteins (IDPs), whose
importance for biological function is widely accepted. However, disordered proteins are not …

The structural polymorphism in β-amyloid (Aβ) plaques from Alzheimer disease (AD) has
been recognized as an important pathological factor. Plaques from sporadic AD patients …

Solvent dynamics strongly induce the fibrillation of an amyloidogenic system. Probing the
solvation mechanism is crucial as it enables us to predict different proteins' functionalities …

Amyloid-β (Aβ) fibrils and plaques are one of the hallmarks of Alzheimer's disease. While the
kinetics of fibrillar growth of Aβ have been extensively studied, several vital questions …

Alzheimer's disease (AD) is one of the most common of the multifactorial diseases and is
characterized by a range of abnormal molecular processes, such as the accumulation of …