Synthetic approaches, functionalization and therapeutic potential of quinazoline and quinazolinone skeletons: The advances continue
The presence of N-heterocycles as an essential structural motif in a variety of biologically
active substances has stimulated the development of new strategies and technologies for …
active substances has stimulated the development of new strategies and technologies for …
Discovery of the Bruton's Tyrosine Kinase Inhibitor Clinical Candidate TAK-020 (S)-5-(1-((1-Acryloylpyrrolidin-3-yl)oxy)isoquinolin-3-yl)-2,4-dihydro-3H-1,2,4-triazol …
M Sabat, DR Dougan, B Knight… - Journal of Medicinal …, 2021 - ACS Publications
This publication details the successful use of FBDD (fragment-based drug discovery)
principles in the invention of a novel covalent Bruton's tyrosine kinase inhibitor, which …
principles in the invention of a novel covalent Bruton's tyrosine kinase inhibitor, which …
A DMAP-catalyzed mild and efficient synthesis of 1, 2-dihydroquinazolines via a one-pot three-component protocol
C Derabli, R Boulcina, G Kirsch, B Carboni… - Tetrahedron …, 2014 - Elsevier
An efficient and simple method for the synthesis of 1, 2-dihydroquinazolines catalyzed by 4-
(N, N-dimethylamino) pyridine (DMAP) from readily available aromatic or heteroaromatic …
(N, N-dimethylamino) pyridine (DMAP) from readily available aromatic or heteroaromatic …
Structure and antioxidant activities of sulfated guar gum: Homogeneous reaction using DMAP/DCC catalyst
J Wang, B Zhao, X Wang, J Yao, J Zhang - International Journal of …, 2012 - Elsevier
It was essential to understand the chemical structure of polysaccharides for further research
and biochemical or medical application of this natural biopolymer. In the present study …
and biochemical or medical application of this natural biopolymer. In the present study …
An efficient and expeditious synthesis of 1, 2, 4-triazolidine-3-thiones using meglumine as a reusable catalyst in water
A simple, convenient, and eco-friendly procedure has been developed using meglumine (15
mol%) as a green catalyst for the synthesis of 1, 2, 4-triazolidine-3-thiones under one-pot …
mol%) as a green catalyst for the synthesis of 1, 2, 4-triazolidine-3-thiones under one-pot …
DMAP catalyzed synthesis of some new pyrrolo[3,2-e][1,2,4]triazolo[1,5-c]pyrimidines
M Khashi, A Davoodnia… - Research on Chemical …, 2015 - Springer
Abstract Starting from 2-amino-1-methyl-4, 5-diphenyl-1 H-pyrrole-3-carbonitrile, the
synthesis of some new tricyclic pyrrolo [3, 2-e][1, 2, 4] triazolo [1, 5-c] pyrimidines catalyzed …
synthesis of some new tricyclic pyrrolo [3, 2-e][1, 2, 4] triazolo [1, 5-c] pyrimidines catalyzed …
Synthesis of 3-(tri/difluoromethyl)-1 H-1, 2, 4-triazol-5 (4 H)-ones via the cyclization of hydrazinecarboxamides with tri/difluoroacetic anhydride
Y You, Y Chen, C You, J Wang, Z Weng - Organic & Biomolecular …, 2019 - pubs.rsc.org
An efficient method for the synthesis of structurally diverse 4-aryl-3-(tri/difluoromethyl)-1H-1,
2, 4-triazol-5 (4H)-ones through the cyclization of hydrazinecarboxamides with …
2, 4-triazol-5 (4H)-ones through the cyclization of hydrazinecarboxamides with …
DMAP-catalyzed synthesis of novel pyrrolo [2, 3-d] pyrimidine derivatives Bearing an aromatic sulfonamide moiety
4-(N, N-Dimethylamino) pyridine (DMAP), with a dual role as a basic nucleophilic catalyst,
was shown to be a highly efficient catalyst for the synthesis of some new N-(2-aryl-7-benzyl …
was shown to be a highly efficient catalyst for the synthesis of some new N-(2-aryl-7-benzyl …
The base-promoted cyclization of N-Boc arylimidrazone toward 1, 2-dihydro 3H-1, 2, 4-triazol-3-ones
X Hu, T Gong, Z Yao, Z Wang, J Cheng - Tetrahedron Letters, 2024 - Elsevier
We reported the base-promoted cyclization of N-Boc arylimidrazone toward 1, 2-dihydro 3H-
1, 2, 4-triazol-3-one. This procedure tolerated methyl, methoxy, chloro, bromo, fluoro, cyano …
1, 2, 4-triazol-3-one. This procedure tolerated methyl, methoxy, chloro, bromo, fluoro, cyano …
Catalytic synthesis of sulfated polysaccharides I: Characterization of chemical structure
J Wang, W Yang, T Yang, X Zhang, Y Zuo, J Tian… - International journal of …, 2015 - Elsevier
In the present study, sulfated derivatives of Artemisia sphaerocephala polysaccharide
(SASP) with high degree of substitution (DS) were synthesized by using 4 …
(SASP) with high degree of substitution (DS) were synthesized by using 4 …