Progress in simulation studies of insulin structure and function

B Gorai, H Vashisth - Frontiers in endocrinology, 2022 - frontiersin.org
Insulin is a peptide hormone known for chiefly regulating glucose level in blood among
several other metabolic processes. Insulin remains the most effective drug for treating …

Role of vitamins in the metabolic syndrome and cardiovascular disease

A Aguilera-Méndez, D Boone-Villa… - … -European Journal of …, 2022 - Springer
The prevalence of metabolic syndrome and cardiovascular disease has increased and
continues to be the leading cause of mortality worldwide. The etiology of these diseases …

Glycation restrains open-closed conformation of Insulin

J Jeevanandam, E Paramasivam… - … Biology and Chemistry, 2023 - Elsevier
In hyperglycemic conditions, the level of reactive dicarbonyl metabolites concentration is
found to be high, which plays a significant role in protein glycation. Despite decades of …

Concentration-dependent mechanism of the binding behavior of ibuprofen to the cell membrane: A molecular dynamic simulation study

M Ghorbani, G Dehghan, A Allahverdi - Journal of Molecular Graphics and …, 2023 - Elsevier
Ibuprofen is a commonly used drug for treating headaches, pain, and fever. The lipid bilayer
is the primary and most important interface for drugs to interact with biological systems …

Insulin adsorption onto PE and PVC tubings

N Tokhadzé, M Sahnoune, J Devémy… - ACS Applied Bio …, 2022 - ACS Publications
We investigate the adsorption of insulin onto PE and PVC materials by using HPLC
measurements and computer simulations. We interpret the experiments by calculating the …

A computational study of the R120G mutation in human αB-crystallin: implications for structural stability and functionality

M Darvazi, M Ghorbani, S Ramazi… - Journal of …, 2024 - Taylor & Francis
The eye is a vital organ in the visual system, which is composed of transparent vascular
tissue. αB-crystallin, a significant protein found in the lens, plays a crucial role in our …

In silico exploration of disulfide derivatives of Ferula foetida oleo-gum (Covexir®) as promising therapeutics against SARS-CoV-2

H Hashemzadeh, M Iranshahy, M Iranshahi… - Computers in Biology …, 2022 - Elsevier
Although vaccines have been significantly successful against coronavirus, due to the high
rate of the Omicron variant spread many researchers are trying to find efficient drugs against …

Phthalate's multiple hormonal effects and their supplementary dietary regulation scheme of health risks for children

Z Han, J Xue, Y Li - Environmental Science and Pollution Research, 2022 - Springer
Four common phthalic acid esters (PAEs), namely, butylbenzyl phthalate (BBzP), dibutyl
phthalate (DBP), di (2-ethylhexyl) phthalate (DEHP), and di-n-octyl phthalate (DNOP) that …

[HTML][HTML] 基于计算模拟与响应面分析漆酶对己烯雌酚的降解作用

刘红艳, 谢世伟, 唐琳, 张文强, 张国琴, 朱义年, 单杨 - 环境科学学报, 2020 - html.rhhz.net
己烯雌酚(Diethylstilbestrol, DES) 作为水环境中最具雌激素活性的合成化合物之一,
其给生物体和环境带来的危害已经引起人们的关注. 本研究首先通过分子对接与分子动力学模拟 …

Fat-Soluble Vitamin Intake Levels and Their Relationship with Health and Markers of Inflammation in the United States Population

MAR MacPherson - 2022 - search.proquest.com
Fat-soluble vitamins and their influence on mental and physical health outcomes amongst
the United States population are not well understood. Quantitative secondary data from the …