Invasion and metastasis are critical determinants of cancer morbidity. Genes and molecules
participating in these steps must be regarded as potential prognostic factors. Growth factors …

In current models of cell cycle control, the transition between different cell cycle states is
regulated at checkpoints. Transition through the cell-cycle is induced by a family of protein …

Introduction Gastric cancer is a fatal malignancy with a rising incidence rate. Effective
methods for early diagnosis, monitoring metastasis, and prognosis are currently unavailable …

To gain molecular understanding of carcinogenesis, progression, and diversity of gastric
cancer, 22 primary human advanced gastric cancer tissues and 8 noncancerous gastric …

Promoter methylation acts as an important alternative to genetic alterations for gene
inactivation in gastric carcinogenesis. Although a number of gastric cancer-associated …

The retinoblastoma (Rb) pathway controls the G1-S checkpoint of the cell cycle. Inactivating
mutations and deletions of p16 and Rb and up-regulation of cyclin D1 disrupt this pathway …

Gastric cancer is the second common malignant neoplasia in Japan, and its poorly
differentiated form is a deadly disease. To identify novel candidate oncogenes contributing …

Background The product of CDKN2A, p16 is an essential regulator of the cell cycle
controlling the entry into the S-phase. Herein, we evaluated CDKN2A promoter methylation …

The INK4a/ARF locus (9p21) encodes two unique and unrelated cell cycle regulators,
p16INK4a and p14ARF. This study was performed to evaluate the methylation status of …

Oncogene research over the last century has been one of the major advances in
understanding the molecular biology of malignant disease. Oncogenes are a structurally …