Rational design of selective small-molecule inhibitors for β-catenin/B-cell lymphoma 9 protein–protein interactions
LR Hoggard, Y Zhang, M Zhang, V Panic… - Journal of the …, 2015 - ACS Publications
Selective inhibition of α-helix-mediated protein–protein interactions (PPIs) with small organic
molecules provides great potential for the discovery of chemical probes and therapeutic …
molecules provides great potential for the discovery of chemical probes and therapeutic …
Fragment hopping-based discovery of novel sulfinylacetamide-diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors
S Han, Y Sang, Y Wu, Y Tao, C Pannecouque… - European Journal of …, 2020 - Elsevier
The fragment hopping approach is widely applied in drug development. A series of
diarylpyrimidines (DAPYs) were obtained by hopping the thioacetamide scaffold to novel …
diarylpyrimidines (DAPYs) were obtained by hopping the thioacetamide scaffold to novel …
Fragment hopping protocol for the design of small-molecule protein–protein interaction inhibitors
SR Kell, Z Wang, H Ji - Bioorganic & Medicinal Chemistry, 2022 - Elsevier
Fragment-based ligand discovery (FBLD) is one of the most successful approaches to
designing small-molecule protein–protein interaction (PPI) inhibitors. The incorporation of …
designing small-molecule protein–protein interaction (PPI) inhibitors. The incorporation of …
Hot spot-based design of small-molecule inhibitors for protein-protein interactions
H Ji - Targeting Protein-Protein Interactions by Small …, 2018 - Springer
Protein-protein interactions (PPIs) are important targets for the development of chemical
probes and therapeutic agents. From the initial discovery of the existence of hot spots at PPI …
probes and therapeutic agents. From the initial discovery of the existence of hot spots at PPI …