Publisher Summary It is known for some time that malignant transformation of human cells
may be associated with the appearance of tumor associated antigens (TAA). Decades of …

Some cancer patients mount spontaneous T‐and B‐cell responses against their tumor cells.
Autologous tumor reactive CD8 cytolytic T lymphocyte (CTL) and CD4 T‐cell clones as well …

Twenty-five patients with high-risk resected stages IIB, III, and IV melanoma were immunized
with a vaccine consisting of the minimal epitope, immunodominant 9-amino acid peptide …

Alopecia areata is a tissue restricted autoimmune condition affecting the hair follicle,
resulting in hair loss. The goal of this study was to test the hypothesis that the autoantigen of …

Dendritic cells (DCs) have been shown to enhance anti-tumor immune responses in several
preclinical models. Furthermore, DC-like function can be elicited from peripheral blood …

Background T cells play a central role in the antitumor response. However, they often face
numerous hurdles in the tumor microenvironment, including the scarcity of available …

The pathology of humans, in contrast to that of inbred laboratory animals faces the challenge
of diversity addressed in genetic terms as polymorphism. Thus, unsurprisingly, treatment …

A prediction of the theory of immunologic surveillance is that tumour antigens can be
recognised by cell‐mediated immunity during early development of the primary tumour by …

Sixty cancer cell lines have been extensively characterized and used by the National
Cancer Institute's Developmental Therapeutics Program (NCI-60) since the early 90's as …

Dendritic cells are unique in their capacity to process antigens and prime naive CD8+ T
cells. Contrary to most cells, which express the standard proteasomes, dendritic cells …