Cancer therapy is a significant challenge due to insufficient drug delivery to the cancer cells
and non-selective killing of healthy cells by most chemotherapy agents. Nano-formulations …

Lipid–protein interactions in cells are involved in various biological processes, including
metabolism, trafficking, signaling, host–pathogen interactions, and transmembrane …

Membrane proteins function in native cell membranes, but extraction into isolated particles is
needed for many biochemical and structural analyses. Commonly used detergent-extraction …

Membrane proteins (MPs) play essential roles in numerous cellular processes. Because
around 70% of the currently marketed drugs target MPs, a detailed understanding of their …

Abstract Structure determination of membrane proteins is critical to the molecular
understanding of many life processes, yet it has historically been a technically challenging …

Detergents are widely used for membrane protein solubilization, purification, and structural
analysis. Over the past two decades, much effort has been made to design novel detergents …

Integral membrane proteins (IMPs) fulfill important physiological functions by providing cell–
environment, cell–cell and virus–host communication; nutrients intake; export of toxic …

Polymer‐based nanodiscs are valuable tools in biomedical research that can offer a
detergent‐free solubilization of membrane proteins maintaining their native lipid …

Polymer lipid nanodiscs are an invaluable system for structural and functional studies of
membrane proteins in their near‐native environment. Despite the recent advances in the …

A third of the genes in prokaryotic and eukaryotic genomes encode membrane proteins that
are either essential for signal transduction and solute transport or function as scaffold …