Association between insulin resistance and the development of cardiovascular disease

V Ormazabal, S Nair, O Elfeky, C Aguayo… - Cardiovascular …, 2018 - Springer
For many years, cardiovascular disease (CVD) has been the leading cause of death around
the world. Often associated with CVD are comorbidities such as obesity, abnormal lipid …

[HTML][HTML] Metabolic syndrome: risk factors, diagnosis, pathogenesis, and management with natural approaches

SM Mohamed, MA Shalaby, RA El-Shiekh… - Food Chemistry …, 2023 - Elsevier
Metabolic syndrome (MetS) is a bunch of metabolic defects comprising hypertension, insulin
resistance, visceral obesity, fatty liver, and atherogenic cardiovascular diseases. Lifestyle …

Pioglitazone after ischemic stroke or transient ischemic attack

WN Kernan, CM Viscoli, KL Furie… - … England Journal of …, 2016 - Mass Medical Soc
Background Patients with ischemic stroke or transient ischemic attack (TIA) are at increased
risk for future cardiovascular events despite current preventive therapies. The identification …

Nonalcoholic fatty liver disease and chronic vascular complications of diabetes mellitus

G Targher, A Lonardo, CD Byrne - Nature reviews endocrinology, 2018 - nature.com
Nonalcoholic fatty liver disease (NAFLD) and diabetes mellitus are common diseases that
often coexist and might act synergistically to increase the risk of hepatic and extra-hepatic …

Metabolic functions of FABPs—mechanisms and therapeutic implications

GS Hotamisligil, DA Bernlohr - Nature Reviews Endocrinology, 2015 - nature.com
Intracellular and extracellular interactions with proteins enables the functional and
mechanistic diversity of lipids. Fatty acid-binding proteins (FABPs) were originally described …

Obesity and cancer—mechanisms underlying tumour progression and recurrence

J Park, TS Morley, M Kim, DJ Clegg… - Nature Reviews …, 2014 - nature.com
Over the past several years, the field of cancer research has directed increased interest
towards subsets of obesity-associated tumours, which include mammary, renal …

[HTML][HTML] Metabolic syndrome, aging and involvement of oxidative stress

F Bonomini, LF Rodella, R Rezzani - Aging and disease, 2015 - ncbi.nlm.nih.gov
The prevalence of the metabolic syndrome, a cluster of cardiovascular risk factors
associated with obesity and insulin resistance, is dramatically increasing in Western and …

Oxidative stress and diabetic complications

F Giacco, M Brownlee - Circulation research, 2010 - Am Heart Assoc
Oxidative stress plays a pivotal role in the development of diabetes complications, both
microvascular and cardiovascular. The metabolic abnormalities of diabetes cause …

Increased oxidative stress in obesity: implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer

M Matsuda, I Shimomura - Obesity research & clinical practice, 2013 - Elsevier
Obesity, especially of the abdominal type, is a health problem that constitutes metabolic
syndrome and increases the incidence of various diseases, including diabetes …

Anti-inflammatory effects of resveratrol: Mechanistic insights

D de Sá Coutinho, MT Pacheco, RL Frozza… - International journal of …, 2018 - mdpi.com
Inflammation is the principal response invoked by the body to address injuries. Despite
inflammation constituting a crucial component of tissue repair, it is well known that …