Radiotherapy is one of the major cancer treatment strategies. Exposure to penetrating
radiation causes cellular stress, directly or indirectly, due to the generation of reactive …

Activation of epithelial–mesenchymal transition (EMT) is thought to be an essential step for
cancer metastasis. Tumor cells undergo EMT in response to a diverse range of extra-and …

Tumor associated fibroblasts (TAFs) are key stromal cells mediating the desmoplastic
reaction and being partially responsible for the drug-resistance and immunosuppressive …

Malignantly transformed cells must alter their metabolic status to stay viable in a harsh
microenvironment and maintain their ability to invade and spread. Anoikis, a specific …

Endoplasmic reticulum (ER) stress has considerable impact on cell growth, proliferation,
metastasis, invasion, angiogenesis and chemoradiotherapy resistance in various cancers …

Radiation-induced pulmonary fibrosis (RIPF) is a common complication in patients with lung
cancer and breast cancer after receiving thoracic radiotherapy. The average incidence of …

Abstract Background Glioblastoma Multiforme (GBM) is a malignant primary brain tumor in
which the standard treatment, ionizing radiation (IR), achieves a median survival of about 15 …

Background Radiotherapy (RT) is one of the major therapeutic approaches to hepatocellular
carcinoma (HCC). Ionizing radiation (IR) inducing the generation of reactive oxygen species …

Silicosis is a progressive fibrotic disease of lung tissue caused by long-term inhalation of
SiO2. However, relatively few studies of the direct effects of SiO2 on lung fibroblasts have …

Radiotherapy is a key treatment option for a wide variety of human tumors, employed either
alone or alongside with other therapeutic interventions. Radiotherapy uses high-energy …