Discovery of Potent Isoquinolinequinone N-Oxides to Overcome Cancer Multidrug Resistance
RD Kruschel, MAG Barbosa, MJ Almeida… - Journal of Medicinal …, 2024 - ACS Publications
Multidrug resistance (MDR) of human tumors has resulted in an immediate need to develop
appropriate new drugs. This work outlines the development of 20 potent IQQ N-oxide …
appropriate new drugs. This work outlines the development of 20 potent IQQ N-oxide …
Bioactivities and structure–activity relationships of natural tetrahydroanthraquinone compounds: a review
S Feng, W Wang - Frontiers in Pharmacology, 2020 - frontiersin.org
Tetrahydroanthraquinones are a kind of important microbial secondary metabolites with
promising biological activities. Most of them were found in microorganisms, a few were …
promising biological activities. Most of them were found in microorganisms, a few were …
[HTML][HTML] Density-fitted open-shell symmetry-adapted perturbation theory and application to π-stacking in benzene dimer cation and ionized DNA base pair steps
JF Gonthier, CD Sherrill - The Journal of Chemical Physics, 2016 - pubs.aip.org
Symmetry-Adapted Perturbation Theory (SAPT) is one of the most popular approaches to
energy component analysis of non-covalent interactions between closed-shell systems …
energy component analysis of non-covalent interactions between closed-shell systems …
[HTML][HTML] Structure-based strategies for synthesis, lead optimization and biological evaluation of N-substituted anthra [1, 2-c][1, 2, 5] thiadiazole-6, 11-dione derivatives …
AAA Ali, YR Lee, ATH Wu, VK Yadav, DS Yu… - Arabian Journal of …, 2021 - Elsevier
As part of our research on developing multi-target small molecule anticancer agents, we
designed, synthesized, and biologically evaluated a series of novel diversified analogues …
designed, synthesized, and biologically evaluated a series of novel diversified analogues …
Isoquinolinequinone N-oxides as anticancer agents effective against drug resistant cell lines
RD Kruschel, A Buzid, UBR Khandavilli… - Organic & …, 2020 - pubs.rsc.org
The isoquinolinequinone (IQQ) pharmacophore is a privileged framework in known cytotoxic
natural product families, caulibugulones and mansouramycins. Exploiting both families as a …
natural product families, caulibugulones and mansouramycins. Exploiting both families as a …
Red Fluorescent Chlamydia trachomatis Applied to Live Cell Imaging and Screening for Antibacterial Agents
In this study, we describe the application of a transformed Chlamydia trachomatis strain
constitutively expressing the red fluorescent protein mCherry, to allow real-time monitoring …
constitutively expressing the red fluorescent protein mCherry, to allow real-time monitoring …
Targeting the C-terminus of Hsp90 as a cancer therapy
J McConnell, Y Wang, S McAlpine - Heat Shock Protein Inhibitors: Success …, 2016 - Springer
Classical Hsp90 inhibitors target the N-terminal ATP binding site. While these inhibitors
have had some clinical success, treatment with these molecules leads to a dramatic …
have had some clinical success, treatment with these molecules leads to a dramatic …
Fungos endofíticos associados à Fridericia platyphylla (Cham.) LG Lohmann (Bignoniaceae): estudo químico e citotoxicidade de extratos brutos
LC Rodrigues - 2023 - teses.usp.br
Microorganismos representam uma fonte promissora e relevante de compostos bioativos
com aplicações farmacológicas e agrícolas. Dentre eles, os fungos endofíticos têm sido alvo …
com aplicações farmacológicas e agrícolas. Dentre eles, os fungos endofíticos têm sido alvo …
[PDF][PDF] Isoquinolinequinone N-oxides as anticancer agents effective against drug
RD Kruschel, A Buzid, UBR Khandavilli, SE Lawrence… - 2019 - academia.edu
The isoquinolinequinone (IQQ) pharmacophore is a privileged framework in known cytotoxic
natural product families, caulibugulones and mansouramycins. Exploiting both families as a …
natural product families, caulibugulones and mansouramycins. Exploiting both families as a …
[PDF][PDF] Isoquinolinequinone N-oxides as anticancer agents effective
RD Kruschel, A Buzid, UB Khandavilli - 2019 - cora.ucc.ie
The isoquinolinequinone (IQQ) pharmacophore is a privileged framework in known cytotoxic
natural product families, caulibugulones and mansouramycins. Exploiting both families as a …
natural product families, caulibugulones and mansouramycins. Exploiting both families as a …