As a crucial component of brain innate immunity, neuroinflammation initially contributes to
neuronal tissue repair and maintenance. However, chronic inflammatory processes within …

Epilepsy is a brain disease associated with epileptic seizures as well as with
neurobehavioral outcomes of this condition. In the last century, inflammation emerged as a …

Background Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous
system (CNS), characterized by neuroinflammation, demyelination, and neurodegeneration …

We aimed to determine the effect of soluble epoxide hydrolase (sEH) inhibition on chronic
experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis …

Experimental autoimmune encephalomyelitis (EAE) is a T cell-mediated inflammatory
autoimmune disease model of multiple sclerosis (MS). The inflammatory process is initiated …

Bioactive lipids, or lipid mediators, are utilized for intercellular communications. They are
rapidly produced in response to various stimuli and exported to extracellular spaces …

The cyclooxygenase (COX)/prostaglandin E2 (PGE2) signaling pathway has emerged as a
critical target for anti-inflammatory therapeutic development in neurological diseases …

Background: Cancer is one of the most life-threatening diseases worldwide. Since
inflammation is considered to be one of the known characteristics of cancer, the activity of …

Recent evidence suggests that clozapine and quetiapine (atypical antipsychotics), tamoxifen
(selective-estrogen receptor modulator) and pioglitazone (PPARγ agonist) may improve …

Background and Objective: Multiple sclerosis (MS) is an inflammatory neurodegenerative
disease characterized by destruction of oligodendrocytes, immune cell infiltration and …