The accurate and complete replication of genomic DNA is essential for all life. In eukaryotic
cells, the assembly of the multi-enzyme replisomes that perform replication is divided into …

Protein modifications provide cells with exquisite temporal and spatial control of protein
function. Ubiquitin is among the most important modifiers, serving both to target hundreds of …

Structure-specific endonucleases resolve DNA secondary structures generated during DNA
repair and recombination. The yeast 5′ flap endonuclease Slx1-Slx4 has received …

The evolutionarily conserved cullin family proteins can assemble as many as 400 distinct E3
ubiquitin ligase complexes that regulate diverse cellular pathways. CUL4, one of three …

Introduction Chromosome replication is initiated by a universal mechanism in eukaryotic
cells. This mechanism entails the assembly and activation at replication origins of the DNA …

The eukaryotic replisome is a crucial determinant of genome stability, but its structure is still
poorly understood. We found previously that many regulatory proteins assemble around the …

Eukaryotic cell cycle transitions are driven by E3 ubiquitin ligases that catalyze the
ubiquitylation and destruction of specific protein targets. For example, the anaphase …

Telomeres protect chromosome ends from fusion and degradation. In the absence of a
specific telomere elongation mechanism, their DNA shortens progressively with every round …

Nucleosome assembly following DNA replication and gene transcription is important to
maintain genome stability and epigenetic information. Newly synthesized histones H3-H4 …

Abstract mRNAs translation to proteins constitutes an important step of cellular gene
expression that is highly regulated in response to different extracellular stimuli and stress …