Human NCR3 gene variants rs2736191 and rs11575837 alter longitudinal risk for development of pediatric malaria episodes and severe malarial anemia

CO Onyango, Q Cheng, EO Munde, E Raballah… - BMC genomics, 2023 - Springer
Background Plasmodium falciparum malaria is a leading cause of pediatric morbidity and
mortality in holoendemic transmission areas. Severe malarial anemia [SMA, hemoglobin …

An elevated level of interleukin-17A in a Senegalese malaria cohort is associated with rs8193038 IL-17A genetic variant

F Thiam, G Diop, C Coulonges, C Derbois… - BMC Infectious …, 2024 - Springer
Malaria infection is a multifactorial disease partly modulated by host immuno-genetic factors.
Recent evidence has demonstrated the importance of Interleukin-17 family proinflammatory …

Genetic variation in interleukin-7 is associated with a reduced erythropoietic response in Kenyan children infected with Plasmodium falciparum

LE Kisia, P Kempaiah, SB Anyona, EO Munde… - BMC Medical …, 2019 - Springer
Background Severe malarial anemia (SMA) is a leading cause of malaria-related morbidity
and mortality in children. The genetic factors that influence development of SMA and …

Fetal origins of malarial disease: cord blood cytokines as risk markers for pediatric severe malarial anemia

EB Brickley, AM Wood, E Kabyemela… - The Journal of …, 2015 - academic.oup.com
Background. Severe malarial anemia (SMA) remains a major cause of pediatric illness and
mortality in Sub-Saharan Africa. Here we test the hypothesis that prenatal exposures …

Malaria, schistosomiasis, and related anemia

GI Gasim, I Adam - Nutritional Deficiency, 2016 - books.google.com
Parasitic infections (eg, malaria and helminthiases) have a huge impact on public health in
endemic areas. Moreover, parasitic infestations are prominent causes of anemia in the …

IL-33/ST2 contributes to severe symptoms in Plasmodium chabaudi-infected BALB/c mice

T Seki, K Obata-Ninomiya… - Parasitology …, 2018 - Elsevier
It has been reported that IL-33 contributes to potentiation of Th2 inflammatory diseases and
protection against helminth infection. Increased plasma IL-33 levels have been observed in …

Eryptosis of non-parasitized erythrocytes is related to anemia in Plasmodium berghei low parasitema malaria of Wistar rats

PRR Totino, HAS de Souza, EHC Correa… - Parasitology …, 2019 - Springer
It is known that premature elimination of non-parasitized RBCs (nRBCs) plays an important
role in the pathogenesis of malarial anemia, in which suicidal death process (eryptosis) of …

IL-13 gene polymorphism at the-1055 locus and severe malaria–Is there a link?

DA Hassan, AB Elhussein, MSB Ali, OE Fadlelseed… - 2024 - researchsquare.com
Objective This research examined how the IL-13-1055C/T promoter polymorphism affects
the likelihood of Sudanese children developing severe malaria. Method The research was …

Human NCR3 gene variants rs2736191 and rs11575837 influence susceptibility to the longitudinal development of pediatric severe malarial anemia

O Onyango Clinton, Q Cheng, EO Munde, E Raballah… - 2022 - edocs.maseno.ac.ke
Plasmodium falciparum malaria is a leading cause of pediatric morbidity and mortality in
holoendemic transmission areas. Severe malarial anemia [SMA, hemoglobin (Hb)< 5.0 g/dL] …

Interleukin-17A Serum Level, IL-17A Genetic Polymorphisms and Severe Malaria Disease

F THIAM, D Gora, C COULONGES, C DERBOIS… - 2023 - preprints.org
Malaria infection is a multifactorial disease partly modulated by host immuno-genetic factors.
Recent evidence has demonstrated the importance of Interleukin-17 family proinflammatory …