Abstract Purpose of Review Metabolic syndrome (MetS), also called the 'deadly
quartet'comprising obesity, diabetes, dyslipidemia, and hypertension, has been ascertained …

Degenerative musculoskeletal diseases are structural and functional failures of the
musculoskeletal system, including osteoarthritis, osteoporosis, intervertebral disc …

Osteoarthritis (OA) is increasing in prevalence and has a severe impact on patients' lives.
However, our understanding of biomarkers driving OA risk remains limited. We developed a …

The relation between obesity and osteoarthritis (OA) development has been traditionally
explained as consequence of the excessive joint effort derived of overweight. However, in …

Rationale: One of the hallmarks of osteoarthritis (OA), the most common degenerative joint
disease, is increased numbers of senescent chondrocytes. Targeting senescent …

The annual incidence of metabolic diseases such as diabetes, non-alcoholic fatty liver
disease (NAFLD), osteoporosis, and atherosclerosis (AS) is increasing, resulting in a heavy …

Cardiovascular diseases (CVDs) are the main diseases that endanger human health, and
their risk factors contribute to high morbidity and a high rate of hospitalization. Cell death is …

Background & aims Ankylosing spondylitis (AS) is an inflammatory disease associated with
destructive changes in the skeleton and joints. The exact molecular mechanism of the …

Obesity (Ob), which has dramatically increased in the last decade, is one of the main risk
factors that contribute to the incidence and progression of osteoarthritis (OA). Targeting the …

Pathways leading to osteoarthritis (OA) are diverse depending on the risk factors involved;
thus, developing OA therapeutics has been challenging. Here we report that nuclear protein …