There is intense and widespread interest in developing monoclonal antibodies as
therapeutic agents to treat diverse human disorders. During early-stage antibody discovery …

Our immune systems constantly coevolve with the pathogens that challenge them, as
pathogens adapt to evade our defense responses, with our immune repertoires shifting in …

Accelerated development of monoclonal antibody (mAb) tool reagents is an essential
requirement for the successful advancement of therapeutic antibodies in today's fast-paced …

The opioid overdose crisis primarily driven by potent synthetic opioids resulted in more than
500,000 deaths in the US over the last 20 years. Though naloxone, a short-acting …

Abstract Polyclonal CD8+ CD45RClow/− Tregs are potent regulatory cells able to control
solid organ transplantation rejection and even induce tolerance. However, donor major …

The rat has been extensively used as a small animal model. Many genetically engineered
rat models have emerged in the last two decades, and the advent of gene-specific …

In kidney transplantation, eplet mismatches between donor and recipient have been
associated with de novo donor-specific antibody development. Eplets are theoretically …

Convergence across B-cell receptor (BCR) and antibody repertoires has become
instrumental in prioritizing candidates in recent rapid therapeutic antibody discovery …

Yeast-surface display (YSD) is commonly applied to screen Fab immune or naïve libraries
for binders of predefined target molecules. However, reformatting of isolated variants …

Identification of antibodies targeting diverse functional epitopes on an antigen is highly
crucial for discovering effective therapeutic candidates. Employing a traditional stepwise …