Drug discovery from marine natural products has enjoyed a renaissance in the past few
years. Ziconotide (Prialt; Elan Pharmaceuticals), a peptide originally discovered in a tropical …

Freestanding nonproteinogenic amino acids have long been recognized for their
antimetabolite properties and tendency to be uncovered to reactive functionalities by the …

Although the protein synthesis inhibitor cycloheximide (CHX) has been known for decades,
its precise mechanism of action remains incompletely understood. The glutarimide portion of …

Marine natural products have proven, over the last half‐century, to be effective biological
modulators. These molecules have revealed new targets for cancer therapy as well as …

The structural complexity of many natural products sets them apart from common synthetic
drugs, allowing them to access a biological target space that lies beyond the enzyme active …

Eukaryotic ribosome and cap-dependent translation are attractive targets in the antitumor,
antiviral, anti-inflammatory, and antiparasitic therapies. Currently, a broad array of small …

Small molecule natural products have aided in the discovery and characterization of many
proteins critical to the progression and maintenance of the cell cycle. Identification of the …

Marine invertebrates constantly interact with a wide range of microorganisms in their aquatic
environment and possess an effective defense system that has enabled their existence for …

The discovery of the didemnin family of marine depsipeptides launched an exciting and
intriguing chapter in natural product chemistry. The unusual structure of the didemnin …

Bioactivities of 42 didemnin congeners, either isolated from the marine tunicates
Trididemnun solidum and Aplidium albicans or prepared synthetically and semisynthetically …