Health inequity drives disease biology to create disparities in prostate cancer outcomes
Prostate cancer exerts a greater toll on African American men than on White men of
European descent (hereafter referred to as European American men): the disparity in …
European descent (hereafter referred to as European American men): the disparity in …
Genetic and biological drivers of prostate cancer disparities in Black men
J Gong, DM Kim, MR Freeman, H Kim, L Ellis… - Nature Reviews …, 2024 - nature.com
Black men with prostate cancer have historically had worse outcomes than white men with
prostate cancer. The causes of this disparity in outcomes are multi-factorial, but a potential …
prostate cancer. The causes of this disparity in outcomes are multi-factorial, but a potential …
Cribriform and intraductal prostate cancer are associated with increased genomic instability and distinct genomic alterations
Background Invasive cribriform and intraductal carcinoma (CR/IDC) is associated with
adverse outcome of prostate cancer patients. The aim of this study was to determine the …
adverse outcome of prostate cancer patients. The aim of this study was to determine the …
TACC3 promotes epithelial–mesenchymal transition (EMT) through the activation of PI3K/Akt and ERK signaling pathways
GH Ha, JS Park, EKY Breuer - Cancer letters, 2013 - Elsevier
Transforming acidic coiled-coil protein 3 (TACC3) is a member of the TACC family, essential
for mitotic spindle dynamics and centrosome integrity during mitosis. Mounting evidence …
for mitotic spindle dynamics and centrosome integrity during mitosis. Mounting evidence …
[HTML][HTML] Recurrent copy number alterations in prostate cancer: an in silico meta-analysis of publicly available genomic data
We present a meta-analysis of somatic copy number alterations (CNAs) from 11 publications
that examined 662 prostate cancer patient samples, which were derived from 546 primary …
that examined 662 prostate cancer patient samples, which were derived from 546 primary …
Interactions among genes, tumor biology and the environment in cancer health disparities: examining the evidence on a national and global scale
TA Wallace, DN Martin, S Ambs - Carcinogenesis, 2011 - academic.oup.com
Cancer incidence and mortality rates show great variations across nations and between
population groups. These variations are largely explained by differences in age distribution …
population groups. These variations are largely explained by differences in age distribution …
[HTML][HTML] Integrated genomic analyses identify ERRFI1 and TACC3 as glioblastoma-targeted genes
CG Duncan, PJ Killela, CA Payne, B Lampson… - Oncotarget, 2010 - ncbi.nlm.nih.gov
The glioblastoma genome displays remarkable chromosomal aberrations, which harbor
critical glioblastoma-specific genes contributing to several oncogenetic pathways. To identify …
critical glioblastoma-specific genes contributing to several oncogenetic pathways. To identify …
Biological determinants of health disparities in prostate cancer
DN Martin, AM Starks, S Ambs - Current opinion in oncology, 2013 - journals.lww.com
Biological determinants of health disparities in prostate ca... : Current Opinion in Oncology
Biological determinants of health disparities in prostate cancer : Current Opinion in Oncology …
Biological determinants of health disparities in prostate cancer : Current Opinion in Oncology …
Minireview: the molecular and genomic basis for prostate cancer health disparities
IJ Powell, A Bollig-Fischer - Molecular endocrinology, 2013 - academic.oup.com
Despite more aggressive screening across all demographics and gradual declines in
mortality related to prostate cancer (PCa) in the United States, race disparities persist. For …
mortality related to prostate cancer (PCa) in the United States, race disparities persist. For …
Distinct genomic alterations in prostate tumors derived from African American men
We aim to understand, from acquired genetic alterations in tumors, why African American
(AA) men are more likely to develop aggressive prostate cancer. By analyzing somatic …
(AA) men are more likely to develop aggressive prostate cancer. By analyzing somatic …