Unraveling the Dynamics of Estrogen and Progesterone Signaling in the Endometrium: An Overview

ID Da Silva, V Wuidar, M Zielonka, C Pequeux - Cells, 2024 - pmc.ncbi.nlm.nih.gov
The endometrium is crucial for the perpetuation of human species. It is a complex and
dynamic tissue lining the inner wall of the uterus, regulated throughout a woman's life based …

FoxO1 is a cell-specific core transcription factor for endometrial remodeling and homeostasis during menstrual cycle and early pregnancy

D Adiguzel, C Celik-Ozenci - Human reproduction update, 2021 - academic.oup.com
BACKGROUND Endometrium is a vital multicellular tissue for progression of pregnancy.
Forkhead box O1 (FoxO1) transcription factor plays an important role in the endometrium as …

Reliable identification of endometrial precancers through combined Pax2, β-catenin, and Pten immunohistochemistry

M Aguilar, H Chen, G Rivera-Colon, S Niu… - The American Journal …, 2022 - journals.lww.com
The diagnosis of endometrial atypical hyperplasia/endometrioid intraepithelial neoplasia
(AH/EIN) remains challenging and subjective in some cases, with variable histologic criteria …

[HTML][HTML] Histopathologic diagnosis of endometrial precancers: updates and future directions

H Chen, AL Strickland, DH Castrillon - Seminars in Diagnostic Pathology, 2022 - Elsevier
Early detection of endometrial cancer, especially its precancers, remains a critical and
evolving issue in patient management and the quest to decrease mortality due to …

Nuclear expression of β‐catenin in endometrial hyperplasia as marker of premalignancy

A Travaglino, A Raffone, G Saccone, M Mascolo… - APMIs, 2019 - Wiley Online Library
We aimed to assess (1)‐whether nuclear β‐catenin is a marker of endometrial precancer,
and (2)‐the diagnostic accuracy of β‐catenin immunohistochemistry in the differential …

FOXA2 suppresses endometrial carcinogenesis and epithelial-mesenchymal transition by regulating enhancer activity

SS Sahoo, SG Ramanand, Y Gao… - The Journal of …, 2022 - Am Soc Clin Investig
FOXA2 encodes a transcription factor mutated in 10% of endometrial cancers (ECs), with a
higher mutation rate in aggressive variants. FOXA2 has essential roles in embryonic and …

Fbxw7 is a driver of uterine carcinosarcoma by promoting epithelial-mesenchymal transition

IC Cuevas, SS Sahoo, A Kumar… - Proceedings of the …, 2019 - National Acad Sciences
Uterine carcinosarcoma is an aggressive variant of endometrial carcinoma characterized by
unusual histologic features including discrete malignant epithelial and mesenchymal …

Utility of a Pax2, PTEN, and Β-Catenin panel in the diagnosis of atypical hyperplasia/Endometrioid intraepithelial Neoplasia in endometrial polyps

E Lucas, S Niu, M Aguilar, K Molberg… - The American Journal …, 2023 - journals.lww.com
The diagnosis of atypical hyperplasia/endometrioid intraepithelial neoplasm (AH/EIN) within
endometrial polyps (EMPs) often poses a diagnostic conundrum. Our previous studies …

Biomarkers in the Diagnosis of Endometrial Precancers. Molecular Characteristics, Candidate Immunohistochemical Markers, and Promising Results of Three-Marker …

S Niu, K Molberg, DH Castrillon, E Lucas, H Chen - Cancers, 2024 - mdpi.com
Simple Summary Endometrial carcinoma is a common type of cancer in women, ranking as
the most frequent gynecological cancer and the fourth most common overall. Its occurrence …

CEP55 predicts the poor prognosis and promotes tumorigenesis in endometrial cancer by regulating the Foxo1 signaling

X Zhang, Q Xu, E Li, T Shi, H Chen - Molecular and Cellular Biochemistry, 2023 - Springer
Endometrial cancer is a common gynecologic cancer, which is relevant to many differentially
expressed genes. Centrosomal protein 55 (CEP55) was proved to be aberrantly expressed …