Genotoxic aldehydes in the hematopoietic system
M Wang, FA Dingler, KJ Patel - Blood, The Journal of the …, 2022 - ashpublications.org
Reactive aldehydes are potent genotoxins that threaten the integrity of hematopoietic stem
cells and blood production. To protect against aldehydes, mammals have evolved a family of …
cells and blood production. To protect against aldehydes, mammals have evolved a family of …
[HTML][HTML] Inducible pluripotent stem cell models to study bone marrow failure and MDS predisposition syndromes
Induced pluripotent stem cells (iPSCs) have emerged as powerful tools for in vitro modeling
of bone marrow failure (BMF) syndromes and hereditary conditions predisposing to …
of bone marrow failure (BMF) syndromes and hereditary conditions predisposing to …
Fanconi anemia and Aldehyde Degradation Deficiency Syndrome: Metabolism and DNA repair protect the genome and hematopoiesis from endogenous DNA …
We have identified a set of Japanese children with hypoplastic anemia caused by combined
defects in aldehyde degrading enzymes ADH5 and ALDH2. Their clinical characteristics …
defects in aldehyde degrading enzymes ADH5 and ALDH2. Their clinical characteristics …
Identifying the therapeutic and prognostic role of the CD8+ T cell-related gene ALDH2 in head and neck squamous cell carcinoma
H Zhang, Z Li, Y Zheng - Cancer Informatics, 2022 - journals.sagepub.com
Head and neck squamous cell carcinoma (HNSC) is a widely known malignancy which is
usually diagnosed late and has a poor prognosis. This study focuses on finding a new gene …
usually diagnosed late and has a poor prognosis. This study focuses on finding a new gene …
Effects of the major formaldehyde catalyzer ADH5 on phenotypes of fanconi anemia zebrafish model
A Mu, Z Cao, D Huang, H Hosokawa… - Molecular Biology …, 2023 - Springer
Background Fanconi anemia (FA) is a devastating hereditary disorder for which we
desperately need a novel therapeutic strategy. It is caused by mutations in one of at least 22 …
desperately need a novel therapeutic strategy. It is caused by mutations in one of at least 22 …