Linkage of population-based administrative data is a valuable tool for combining detailed
individual-level information from different sources for research. While not a substitute for …

PURPOSE Antibiotic exposure before immune checkpoint inhibitor (ICI) treatment can
negatively affect outcomes through alteration in the gut microbiome, but large-scale …

Background ICES was founded in 1992 to study the health care system in Ontario and
promote effective, efficient and equitable health care. Over 27 years later, the goal remains …

Objective To characterize youth who use the emergency department (ED) as a “first contact”
for mental health (MH) problems. Method This was a population-based cross-sectional …

Socioeconomic status is an important determinant of health, the measurement of which is of
great significance to population health research. However, individual-level socioeconomic …

Importance Women physicians may delay childbearing and experience childlessness more
often than nonphysicians, but existing knowledge is based largely on self-reported survey …

Background Myocardial infarction mortality has declined since the 1970s, but contemporary
drivers of this trend remain unexplained. The aim of this study was to compare the …

Objectives To determine if bilateral salpingo-oophorectomy, compared with ovarian
conservation, is associated with all cause or cause specific death in women undergoing …

Importance People who immigrate face unique health literacy, communication, and system
navigation challenges, and they may have diverse preferences that influence end-of-life …

Background: When patients and physicians speak the same language, it may improve the
quality and safety of care delivered. We sought to determine whether patient–physician …