Mast Cells, Mastocytosis, and Related Disorders | New England Journal of Medicine Skip to main
content The New England Journal of Medicine homepage Advanced Search SEARCH …

Fibromyalgia Syndrome (FMS) is a disorder of chronic, generalized muscular pain,
accompanied by sleep disturbances, fatigue and cognitive dysfunction. There is no definitive …

Introduction: An increasing number of patients present with multiple symptoms affecting
many organs including the brain due to multiple mediators released by mast cells. These …

Patients with clonal mast cell activation syndromes (MCAS) including cutaneous and
systemic mastocytosis (SM) may present with symptoms of mast cell activation, but in …

Objective Atopic diseases worsen with psychological stress, but how stress contributes to
their pathogenesis is still not clear. We review the evidence supporting the premise that …

Increasing evidence indicates that brain inflammation is involved in the pathogenesis of
neuropsychiatric diseases. Mast cells (MCs) are located perivascularly close to neurons and …

Mast cells (MC) are hemotopoietically derived tissue immune cells that are ubiquitous in the
body, including neuroendocrine organs such as the hypothalamus, pineal, pituitary, ovaries …

Corticotropin-releasing hormone is a critical component of the hypothalamic–pituitary–
adrenal axis, which plays a major role in the body's immune response to stress. Mast cells …

The skin is considered the mirror of the soul and is affected by neurohormonal triggers,
especially stress. Hair follicles, keratinocytes, mast cells, melanocytes, and sebocytes all …

Purpose Psychological stress worsens many diseases, especially those with inflammatory
components, such as atopic dermatitis (AD) and autism spectrum disorder (ASD), conditions …