Recent drug design strategies and identification of key heterocyclic scaffolds for promising anticancer targets
Cancer, a noncommunicable disease, is the leading cause of mortality worldwide and is
anticipated to rise by 75% in the next two decades, reaching approximately 25 million cases …
anticipated to rise by 75% in the next two decades, reaching approximately 25 million cases …
[HTML][HTML] Structural benchmarking, density functional theory simulation, spectroscopic investigation and molecular docking of N-(1H-pyrrol-2-yl) methylene)-4 …
Prostate cancer that is resistant to castration has been a prominent health challenge in the
lives of men, particularly older men. This study looks at the spectroscopic properties, density …
lives of men, particularly older men. This study looks at the spectroscopic properties, density …
Discovery of novel pyrazole and pyrazolo[1,5‐a]pyrimidine derivatives as cyclooxygenase inhibitors (COX‐1 and COX‐2) using molecular modeling simulation
Searching for effective and selective anti‐inflammatory agents, our study involved designing
and synthesizing new pyrazole and pyrazolo [1, 5‐a] pyrimidine derivatives 4–11. The …
and synthesizing new pyrazole and pyrazolo [1, 5‐a] pyrimidine derivatives 4–11. The …
Exploring novel derivatives of isatin-based Schiff bases as multi-target agents: design, synthesis, in vitro biological evaluation, and in silico ADMET analysis with …
Recently, scientists developed a powerful strategy called “one drug-multiple targets” to
discover vital and unique therapies to fight the most challenging diseases. Novel derivatives …
discover vital and unique therapies to fight the most challenging diseases. Novel derivatives …
In vitro enzymatic evaluation of some pyrazolo[1,5‐a]pyrimidine derivatives: Design, synthesis, antioxidant, anti‐diabetic, anti‐Alzheimer, and anti‐arthritic activities …
AS Hassan, NM Morsy… - Drug Development …, 2023 - Wiley Online Library
The strategy of utilizing nitrogen compounds in various biological applications has recently
emerged as a powerful approach to exploring novel classes of therapeutics to face the …
emerged as a powerful approach to exploring novel classes of therapeutics to face the …
Development of novel pyrazole, imidazo [1, 2-b] pyrazole, and pyrazolo [1, 5-a] pyrimidine derivatives as a new class of COX-2 inhibitors with immunomodulatory …
Searching for new compounds with anti-inflammatory properties is a significant target since
inflammation is a major cause of pain. A series of pyrazole, imidazopyrazolone, and …
inflammation is a major cause of pain. A series of pyrazole, imidazopyrazolone, and …
Developing a new multi-featured chitosan-quinoline Schiff base with potent antibacterial, antioxidant, and antidiabetic activities: Design and molecular modeling …
YM Abdel-Baky, AM Omer, EM El-Fakharany… - Scientific reports, 2023 - nature.com
A new chitosan Schiff base was developed via the reaction of chitosan (CH) with 2-chloro-3-
formyl-7-ethoxy quinoline (Q) derivative. The alteration in the chemical structure and …
formyl-7-ethoxy quinoline (Q) derivative. The alteration in the chemical structure and …
Synthesis, characterization, and in vitro antibacterial activity of some new pyridinone and pyrazole derivatives with some in silico ADME and molecular modeling study
KE Saadon, NMH Taha, NA Mahmoud… - Journal of the Iranian …, 2022 - Springer
A new series of pyridine-2-one and pyrazole derivatives were designed and synthesized
based on cyanoacrylamide derivatives containing 2, 4-dichlro aniline and 6-methyl 2-amino …
based on cyanoacrylamide derivatives containing 2, 4-dichlro aniline and 6-methyl 2-amino …
Evaluation of the anti-proliferative activity of 2-oxo-pyridine and 1′ H-spiro-pyridine derivatives as a new class of EGFR Wt and VEGFR-2 inhibitors with apoptotic …
RR Raslan, YA Ammar, SA Fouad, SA Hessein… - RSC …, 2023 - pubs.rsc.org
Developing new agents for cancer treatment remains a top priority because it is one of the
deadliest worldwide. A new series of 2-oxo-pyridine and 1′ H-spiro-pyridine derivatives …
deadliest worldwide. A new series of 2-oxo-pyridine and 1′ H-spiro-pyridine derivatives …
A novel of quinoxaline derivatives tagged with pyrrolidinyl scaffold as a new class of antimicrobial agents: Design, synthesis, antimicrobial activity, and molecular …
MM Abdelgalil, YA Ammar, GAME Ali, AK Ali… - Journal of Molecular …, 2023 - Elsevier
Globally, infectious diseases are becoming harder to treat due to antibiotic resistance, which
has reached high levels. Additionally, developing new therapeutic options to combat the …
has reached high levels. Additionally, developing new therapeutic options to combat the …