The blood-brain barrier: Physiology and strategies for drug delivery

R Pandit, L Chen, J Götz - Advanced drug delivery reviews, 2020 - Elsevier
The blood-brain barrier (BBB) is a dynamic structure that functions as a gatekeeper,
reflecting the unique requirements of the brain. In this review, following a brief historical …

Overcoming the blood–brain barrier for the therapy of malignant brain tumor: current status and prospects of drug delivery approaches

K Mitusova, OO Peltek, TE Karpov… - Journal of …, 2022 - Springer
Besides the broad development of nanotechnological approaches for cancer diagnosis and
therapy, currently, there is no significant progress in the treatment of different types of brain …

Sustainable production of dopamine hydrochloride from softwood lignin

L Dong, Y Wang, Y Dong, Y Zhang, M Pan… - Nature …, 2023 - nature.com
Dopamine is not only a widely used commodity pharmaceutical for treating neurological
diseases but also a highly attractive base for advanced carbon materials. Lignin, the waste …

Therapeutic potential of natural products in treating neurodegenerative disorders and their future prospects and challenges

MH Rahman, J Bajgai, A Fadriquela, S Sharma… - Molecules, 2021 - mdpi.com
Natural products derived from plants, as well as their bioactive compounds, have been
extensively studied in recent years for their therapeutic potential in a variety of …

Dopamine-loaded nanoparticle systems circumvent the blood–brain barrier restoring motor function in mouse model for Parkinson's Disease

V Monge-Fuentes, A Biolchi Mayer, MR Lima… - Scientific reports, 2021 - nature.com
Parkinson's disease (PD) is a progressive and chronic neurodegenerative disease of the
central nervous system. Early treatment for PD is efficient; however, long-term systemic …

DFT, NBO, HOMO-LUMO, NCI, stability, Fukui function and hole–Electron analyses of tolcapone

AD Isravel, JK Jeyaraj, S Thangasamy… - … and Theoretical Chemistry, 2021 - Elsevier
Parkinson's disease is a neurodegenerative disorder that damages the nervous system. The
treatment of this disease is carried using tolcapone as a drug combination with Levodopa …

Roles of clock genes in the pathogenesis of Parkinson's disease

AD Shkodina, SC Tan, MM Hasan… - Ageing Research …, 2022 - Elsevier
Parkinson's disease (PD) is a common motor disorder that has become increasingly
prevalent in the ageing population. Recent works have suggested that circadian rhythms …

[HTML][HTML] Levodopa-loaded nanoparticles for the treatment of Parkinson's disease

EF van Vliet, MJ Knol, RM Schiffelers, M Caiazzo… - Journal of Controlled …, 2023 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disorder characterized by degeneration of
dopaminergic neurons in the substantia nigra pars compacta (SNpc) resulting in dopamine …

The role of neurovascular system in neurodegenerative diseases

A Ahmad, V Patel, J Xiao, MM Khan - Molecular neurobiology, 2020 - Springer
The neurovascular system (NVS), which consisted of neurons, glia, and vascular cells, is a
functional and structural unit of the brain. The NVS regulates blood-brain barrier (BBB) …

[HTML][HTML] Recent advances in prodrug-based nanoparticle therapeutics

KJ Chen, AJ Plaunt, FG Leifer, JY Kang… - European Journal of …, 2021 - Elsevier
Extensive research into prodrug modification of active pharmaceutical ingredients and
nanoparticle drug delivery systems has led to unprecedented levels of control over the …