Cognitive synaptopathy: synaptic and dendritic spine dysfunction in age-related cognitive disorders

FJ Barrantes - Frontiers in Aging Neuroscience, 2024 - frontiersin.org
Cognitive impairment is a leading component of several neurodegenerative and
neurodevelopmental diseases, profoundly impacting on the individual, the family, and …

Head‐to‐head comparison of leading blood tests for Alzheimer's disease pathology

SE Schindler, KK Petersen, B Saef… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION Blood tests have the potential to improve the accuracy of Alzheimer's
disease (AD) clinical diagnosis, which will enable greater access to AD‐specific treatments …

Plasma proteomic evidence for increased β-amyloid pathology after SARS-CoV-2 infection

EP Duff, H Zetterberg, A Heslegrave, A Dehghan… - Nature Medicine, 2025 - nature.com
Previous studies have suggested that systemic viral infections may increase risks of
dementia. Whether this holds true for severe acute respiratory syndrome coronavirus 2 …

[HTML][HTML] Role of Blood P-Tau Isoforms (181, 217, 231) in Predicting Conversion from MCI to Dementia Due to Alzheimer's Disease: A Review and Meta-Analysis

G Lombardi, S Pancani, R Manca, M Mitolo… - International Journal of …, 2024 - mdpi.com
Blood-based biomarkers are minimally invasive tools to detect the pathological changes of
Alzheimer's Disease (AD). This meta-analysis aims to investigate the use of blood-derived p …

[HTML][HTML] PrecivityAD2™ Blood Test: Analytical Validation of an LC-MS/MS Assay for Quantifying Plasma Phospho-tau217 and Non-Phospho-tau217 Peptide …

SM Eastwood, MR Meyer, KM Kirmess, TL Wente-Roth… - Diagnostics, 2024 - mdpi.com
Alzheimer's disease (AD) is a progressive irreversible neurodegenerative disorder that
represents a major global public health concern. Traditionally, AD is diagnosed using …

[HTML][HTML] Serum metabolome profiling in patients with mild cognitive impairment reveals sex differences in lipid metabolism

RD Escarcega, VK MJ, VE Kyriakopoulos, GJ Ortiz… - Neurobiology of …, 2025 - Elsevier
Alzheimer's disease (AD) affects more women than men. Although women live longer than
men, it is not longevity alone, but other factors, including metabolic changes, that contribute …

[HTML][HTML] Saliva Proteome, Metabolome and Microbiome Signatures for Detection of Alzheimer's Disease

M François, D Pascovici, Y Wang, T Vu, JW Liu… - Metabolites, 2024 - mdpi.com
Background: As the burden of Alzheimer's disease (AD) escalates with an ageing
population, the demand for early and accessible diagnostic methods becomes increasingly …

[HTML][HTML] Informing etiological heterogeneity of mild cognitive impairment and risk for progression to dementia with plasma p-tau217

BM Asken, REC Cid, EA Crocco, MJ Armstrong… - The Journal of …, 2025 - Elsevier
Background Mild cognitive impairment (MCI) is a clinical diagnosis representing early
symptom changes with preserved functional independence. There are multiple potential …

Influence of medical conditions on the diagnostic accuracy of plasma p‐tau217 and p‐tau217/Aβ42

M Olvera‐Rojas, KR Sewell, TK Karikari… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION Blood‐based biomarkers (BBMs) can enable early detection of brain
amyloid beta (Aβ) pathology in cognitively unimpaired individuals. However, the extent to …

Timing of changes in Alzheimer's disease plasma biomarkers as assessed by amyloid and tau PET clocks

M Milà-Alomà, D Tosun, SE Schindler, Z Hausle, Y Li… - medRxiv, 2024 - medrxiv.org
Plasma biomarkers for Alzheimer's disease (AD) are increasingly being used to assist in
making an etiological diagnosis for cognitively impaired (CI) individuals or to identify …