Defining precancer: a grand challenge for the cancer community

J Faupel-Badger, I Kohaar, M Bahl, AT Chan… - Nature Reviews …, 2024 - nature.com
The term 'precancer'typically refers to an early stage of neoplastic development that is
distinguishable from normal tissue owing to molecular and phenotypic alterations, resulting …

[HTML][HTML] Circulating Tumor DNA—A Novel Biomarker of Tumor Progression and Its Favorable Detection Techniques

X Wen, H Pu, Q Liu, Z Guo, D Luo - Cancers, 2022 - mdpi.com
Simple Summary ctDNA is a small DNA fragment derived from tumor cells, which contains
tumor-related genomic information, such as mutation, methylation, microsatellite instability …

Polyp-sam: Transfer sam for polyp segmentation

Y Li, M Hu, X Yang - Medical Imaging 2024: Computer-Aided …, 2024 - spiedigitallibrary.org
Automatic segmentation of colon polyps can significantly reduce the misdiagnosis of colon
cancer and improve physician annotation efficiency. While many methods have been …

Early detection of molecular residual disease and risk stratification for stage I to III colorectal cancer via circulating tumor DNA methylation

S Mo, L Ye, D Wang, L Han, S Zhou, H Wang… - JAMA …, 2023 - jamanetwork.com
Importance Detection of molecular residual disease and risk stratification as early as
possible may improve the treatment of patients with cancer. Efficient pragmatic tests are …

Circulating tumor DNA is a variant of liquid biopsy with predictive and prognostic clinical value in breast cancer patients

TM Zavarykina, PK Lomskova, IV Pronina… - International Journal of …, 2023 - mdpi.com
This paper introduces the reader to the field of liquid biopsies and cell-free nucleic acids,
focusing on circulating tumor DNA (ctDNA) in breast cancer (BC). BC is the most common …

Liquid biopsy in lung cancer: biomarkers for the management of recurrence and metastasis

VGP Souza, A Forder, LJ Brockley… - International Journal of …, 2023 - mdpi.com
Liquid biopsies have emerged as a promising tool for the detection of metastases as well as
local and regional recurrence in lung cancer. Liquid biopsy tests involve analyzing a …

Screening for pancreatic cancer has the potential to save lives, but is it practical?

BL Mazer, JW Lee, NJ Roberts, LC Chu… - Expert Review of …, 2023 - Taylor & Francis
Introduction Most patients with pancreatic cancer present with advanced stage, incurable
disease. However, patients with high-grade precancerous lesions and many patients with …

Exploring core genes by comparative transcriptomics analysis for early diagnosis, prognosis, and therapies of colorectal cancer

MA Islam, MB Hossen, MA Horaira, MA Hossen… - Cancers, 2023 - mdpi.com
Simple Summary Colorectal cancer (CRC) is a complex disease that has a high mortality
rate. This study explored CRC-related core genes (CGs) from multiple microarray gene …

Circulating tumor DNA: current implementation issues and future challenges for clinical utility

Q Hu, L Chen, K Li, R Liu, L Sun… - Clinical Chemistry and …, 2024 - degruyter.com
Over the past decades, liquid biopsy, especially circulating tumor DNA (ctDNA), has
received tremendous attention as a noninvasive detection approach for clinical applications …

Comparative effectiveness and cost-effectiveness of colorectal cancer screening with blood-based biomarkers (liquid biopsy) vs fecal tests or colonoscopy

U Ladabaum, A Mannalithara, Y Weng, RE Schoen… - Gastroenterology, 2024 - Elsevier
Background & Aims Colorectal cancer (CRC) screening is highly effective but underused.
Blood-based biomarkers (liquid biopsy) could improve screening participation. Methods …