Wnt/β-catenin signaling in cancers and targeted therapies

F Yu, C Yu, F Li, Y Zuo, Y Wang, L Yao, C Wu… - … and Targeted Therapy, 2021 - nature.com
Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental
cancer models of animals. Aberrant activation of Wnt/β-catenin signaling is tightly linked with …

Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities

X Xu, M Zhang, F Xu, S Jiang - Molecular cancer, 2020 - Springer
Wnt signaling is a highly conserved signaling pathway that plays a critical role in controlling
embryonic and organ development, as well as cancer progression. Genome-wide …

Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex

YS Jung, JI Park - Experimental & Molecular Medicine, 2020 - nature.com
Wnt/β-catenin signaling is implicated in many physiological processes, including
development, tissue homeostasis, and tissue regeneration. In human cancers, Wnt/β-catenin …

Targeting the Wnt/beta-catenin pathway in cancer: Update on effectors and inhibitors

N Krishnamurthy, R Kurzrock - Cancer treatment reviews, 2018 - Elsevier
The Wnt/beta-catenin pathway is a family of proteins that is implicated in many vital cellular
functions such as stem cell regeneration and organogenesis. Several intra-cellular signal …

Protein lipidation: occurrence, mechanisms, biological functions, and enabling technologies

H Jiang, X Zhang, X Chen, P Aramsangtienchai… - Chemical …, 2018 - ACS Publications
Protein lipidation, including cysteine prenylation, N-terminal glycine myristoylation, cysteine
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …

WNT signaling in cardiac and vascular disease

S Foulquier, EP Daskalopoulos, G Lluri… - Pharmacological …, 2018 - Elsevier
WNT signaling is an elaborate and complex collection of signal transduction pathways
mediated by multiple signaling molecules. WNT signaling is critically important for …

Disruption of the circadian clock drives Apc loss of heterozygosity to accelerate colorectal cancer

SK Chun, BM Fortin, RC Fellows, AN Habowski… - Science …, 2022 - science.org
An alarming rise in young onset colorectal cancer (CRC) has been reported; however, the
underlying molecular mechanism remains undefined. Suspected risk factors of young onset …

WNT signaling in disease

LF Ng, P Kaur, N Bunnag, J Suresh, ICH Sung, QH Tan… - Cells, 2019 - mdpi.com
Developmental signaling pathways control a vast array of biological processes during
embryogenesis and in adult life. The WNT pathway was discovered simultaneously in …

Targeting the Wnt/β-catenin signaling pathway as a potential therapeutic strategy in renal tubulointerstitial fibrosis

SS Li, Q Sun, MR Hua, P Suo, JR Chen… - Frontiers in …, 2021 - frontiersin.org
The Wnt/β-catenin signaling pathway plays important roles in embryonic development and
tissue homeostasis. Wnt signaling is induced, and β-catenin is activated, associated with the …

Protein lipidation in cell signaling and diseases: function, regulation, and therapeutic opportunities

B Chen, Y Sun, J Niu, GK Jarugumilli, X Wu - Cell chemical biology, 2018 - cell.com
Protein lipidation is an important co-or posttranslational modification in which lipid moieties
are covalently attached to proteins. Lipidation markedly increases the hydrophobicity of …